*,:before,:after,::backdrop{--tw-border-spacing-x:0;--tw-border-spacing-y:0;--tw-translate-x:0;--tw-translate-y:0;--tw-rotate:0;--tw-skew-x:0;--tw-skew-y:0;--tw-scale-x:1;--tw-scale-y:1;--tw-pan-x: ;--tw-pan-y: ;--tw-pinch-zoom: ;--tw-scroll-snap-strictness:proximity;--tw-gradient-from-position: ;--tw-gradient-via-position: ;--tw-gradient-to-position: ;--tw-ordinal: ;--tw-slashed-zero: ;--tw-numeric-figure: ;--tw-numeric-spacing: ;--tw-numeric-fraction: ;--tw-ring-inset: ;--tw-ring-offset-width:0px;--tw-ring-offset-color:#fff;--tw-ring-color:#3b82f680;--tw-ring-offset-shadow:0 0 #0000;--tw-ring-shadow:0 0 #0000;--tw-shadow:0 0 #0000;--tw-shadow-colored:0 0 #0000;--tw-blur: ;--tw-brightness: ;--tw-contrast: ;--tw-grayscale: ;--tw-hue-rotate: ;--tw-invert: ;--tw-saturate: ;--tw-sepia: ;--tw-drop-shadow: ;--tw-backdrop-blur: ;--tw-backdrop-brightness: ;--tw-backdrop-contrast: ;--tw-backdrop-grayscale: ;--tw-backdrop-hue-rotate: ;--tw-backdrop-invert: ;--tw-backdrop-opacity: ;--tw-backdrop-saturate: ;--tw-backdrop-sepia: ;--tw-contain-size: ;--tw-contain-layout: ;--tw-contain-paint: ;--tw-contain-style: }*,:before,:after{box-sizing:border-box;border:0 solid #e5e7eb}:before,:after{--tw-content:""}html,:host{-webkit-text-size-adjust:100%;tab-size:4;line-height:1.5;font-family:Source Sans 3, Segoe UI, system-ui, sans-serif;font-feature-settings:normal;font-variation-settings:normal;-webkit-tap-highlight-color:transparent}body{line-height:inherit;margin:0}hr{height:0;color:inherit;border-top-width:1px}abbr:where([title]){-webkit-text-decoration:underline dotted;text-decoration:underline dotted}h1,h2,h3,h4,h5,h6{font-size:inherit;font-weight:inherit}a{color:inherit;-webkit-text-decoration:inherit;text-decoration:inherit}b,strong{font-weight:bolder}code,kbd,samp,pre{font-feature-settings:normal;font-variation-settings:normal;font-family:IBM Plex Mono,ui-monospace,monospace;font-size:1em}small{font-size:80%}sub,sup{vertical-align:baseline;font-size:75%;line-height:0;position:relative}sub{bottom:-.25em}sup{top:-.5em}table{text-indent:0;border-color:inherit;border-collapse:collapse}button,input,optgroup,select,textarea{font-feature-settings:inherit;font-variation-settings:inherit;font-family:inherit;font-size:100%;font-weight:inherit;line-height:inherit;letter-spacing:inherit;color:inherit;margin:0;padding:0}button,select{text-transform:none}button,input:where([type=button]),input:where([type=reset]),input:where([type=submit]){-webkit-appearance:button;background-color:#0000;background-image:none}:-moz-focusring{outline:auto}:-moz-ui-invalid{box-shadow:none}progress{vertical-align:baseline}::-webkit-inner-spin-button{height:auto}::-webkit-outer-spin-button{height:auto}[type=search]{-webkit-appearance:textfield;outline-offset:-2px}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-file-upload-button{-webkit-appearance:button;font:inherit}summary{display:list-item}blockquote,dl,dd,h1,h2,h3,h4,h5,h6,hr,figure,p,pre{margin:0}fieldset{margin:0;padding:0}legend{padding:0}ol,ul,menu{margin:0;padding:0;list-style:none}dialog{padding:0}textarea{resize:vertical}input::-moz-placeholder{opacity:1;color:#9ca3af}textarea::-moz-placeholder{opacity:1;color:#9ca3af}input::placeholder,textarea::placeholder{opacity:1;color:#9ca3af}button,[role=button]{cursor:pointer}:disabled{cursor:default}img,svg,video,canvas,audio,iframe,embed,object{vertical-align:middle;display:block}img,video{max-width:100%;height:auto}[hidden]:where(:not([hidden=until-found])){display:none}.sr-only{clip:rect(0, 0, 0, 0);white-space:nowrap;border-width:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}.pointer-events-none{pointer-events:none}.pointer-events-auto{pointer-events:auto}.visible{visibility:visible}.collapse{visibility:collapse}.static{position:static}.fixed{position:fixed}.absolute{position:absolute}.relative{position:relative}.sticky{position:sticky}.inset-0{inset:0}.inset-y-0{top:0;bottom:0}.left-0{left:0}.right-0{right:0}.right-3{right:.75rem}.top-0{top:0}.top-0\.5{top:.125rem}.top-full{top:100%}.isolate{isolation:isolate}.z-0{z-index:0}.z-10{z-index:10}.z-20{z-index:20}.z-30{z-index:30}.z-40{z-index:40}.z-50{z-index:50}.z-\[100\]{z-index:100}.z-\[2000\]{z-index:2000}.mx-2{margin-left:.5rem;margin-right:.5rem}.mx-auto{margin-left:auto;margin-right:auto}.my-2{margin-top:.5rem;margin-bottom:.5rem}.mb-1{margin-bottom:.25rem}.mb-1\.5{margin-bottom:.375rem}.mb-3{margin-bottom:.75rem}.mb-4{margin-bottom:1rem}.mr-1{margin-right:.25rem}.mt-0\.5{margin-top:.125rem}.mt-1{margin-top:.25rem}.mt-1\.5{margin-top:.375rem}.mt-16{margin-top:4rem}.mt-2{margin-top:.5rem}.mt-4{margin-top:1rem}.mt-5{margin-top:1.25rem}.mt-6{margin-top:1.5rem}.block{display:block}.inline-block{display:inline-block}.inline{display:inline}.flex{display:flex}.inline-flex{display:inline-flex}.\!table{display:table!important}.table{display:table}.grid{display:grid}.contents{display:contents}.hidden{display:none}.h-12{height:3rem}.h-14{height:3.5rem}.h-28{height:7rem}.h-3{height:.75rem}.h-3\.5{height:.875rem}.h-4{height:1rem}.h-48{height:12rem}.h-6{height:1.5rem}.h-7{height:1.75rem}.h-8{height:2rem}.h-9{height:2.25rem}.h-\[200px\]{height:200px}.h-\[220px\]{height:220px}.h-\[340px\]{height:340px}.h-full{height:100%}.h-px{height:1px}.h-screen{height:100vh}.max-h-60{max-height:15rem}.max-h-\[90vh\]{max-height:90vh}.min-h-0{min-height:0}.min-h-screen{min-height:100vh}.w-0{width:0}.w-14{width:3.5rem}.w-20{width:5rem}.w-24{width:6rem}.w-3{width:.75rem}.w-3\.5{width:.875rem}.w-32{width:8rem}.w-4{width:1rem}.w-56{width:14rem}.w-6{width:1.5rem}.w-60{width:15rem}.w-8{width:2rem}.w-9{width:2.25rem}.w-\[min\(16\.5rem\,88vw\)\]{width:min(16.5rem,88vw)}.w-full{width:100%}.min-w-0{min-width:0}.min-w-\[1200px\]{min-width:1200px}.max-w-2xl{max-width:42rem}.max-w-6xl{max-width:72rem}.max-w-\[120px\]{max-width:120px}.max-w-\[140px\]{max-width:140px}.max-w-\[160px\]{max-width:160px}.max-w-lg{max-width:32rem}.max-w-md{max-width:28rem}.max-w-none{max-width:none}.flex-1{flex:1}.shrink-0{flex-shrink:0}.border-collapse{border-collapse:collapse}.-translate-x-full{--tw-translate-x:-100%;transform:translate(var(--tw-translate-x), var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-0{--tw-translate-x:0px;transform:translate(var(--tw-translate-x), var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-1{--tw-translate-x:.25rem;transform:translate(var(--tw-translate-x), var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.translate-x-7{--tw-translate-x:1.75rem;transform:translate(var(--tw-translate-x), var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}.transform{transform:translate(var(--tw-translate-x), var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y))}@keyframes spin{to{transform:rotate(360deg)}}.animate-spin{animation:1s linear infinite spin}.cursor-pointer{cursor:pointer}.grid-cols-2{grid-template-columns:repeat(2,minmax(0,1fr))}.grid-cols-3{grid-template-columns:repeat(3,minmax(0,1fr))}.flex-col{flex-direction:column}.flex-wrap{flex-wrap:wrap}.items-start{align-items:flex-start}.items-center{align-items:center}.justify-end{justify-content:flex-end}.justify-center{justify-content:center}.justify-between{justify-content:space-between}.gap-1{gap:.25rem}.gap-1\.5{gap:.375rem}.gap-2{gap:.5rem}.gap-3{gap:.75rem}.gap-4{gap:1rem}.space-y-0\.5>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(.125rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(.125rem * var(--tw-space-y-reverse))}.space-y-1>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(.25rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(.25rem * var(--tw-space-y-reverse))}.space-y-2>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(.5rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(.5rem * var(--tw-space-y-reverse))}.space-y-3>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(.75rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(.75rem * var(--tw-space-y-reverse))}.space-y-4>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(1rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(1rem * var(--tw-space-y-reverse))}.space-y-5>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(1.25rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(1.25rem * var(--tw-space-y-reverse))}.space-y-6>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(1.5rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(1.5rem * var(--tw-space-y-reverse))}.space-y-8>:not([hidden])~:not([hidden]){--tw-space-y-reverse:0;margin-top:calc(2rem * calc(1 - var(--tw-space-y-reverse)));margin-bottom:calc(2rem * var(--tw-space-y-reverse))}.overflow-auto{overflow:auto}.overflow-hidden{overflow:hidden}.overflow-x-auto{overflow-x:auto}.overflow-y-auto{overflow-y:auto}.truncate{text-overflow:ellipsis;white-space:nowrap;overflow:hidden}.whitespace-nowrap{white-space:nowrap}.rounded{border-radius:.25rem}.rounded-full{border-radius:9999px}.rounded-lg{border-radius:6px}.rounded-md{border-radius:.375rem}.border{border-width:1px}.border-0{border-width:0}.border-b{border-bottom-width:1px}.border-r{border-right-width:1px}.border-t{border-top-width:1px}.border-\[var\(--border\)\]{border-color:var(--border)}.border-\[var\(--primary\)\]{border-color:var(--primary)}.border-white\/10{border-color:#ffffff1a}.border-white\/15{border-color:#ffffff26}.bg-\[var\(--bg\)\]{background-color:var(--bg)}.bg-\[var\(--bg-card\)\]{background-color:var(--bg-card)}.bg-\[var\(--bg-elevated\)\]{background-color:var(--bg-elevated)}.bg-\[var\(--bg-header\)\]{background-color:var(--bg-header)}.bg-\[var\(--bg-hover\)\]{background-color:var(--bg-hover)}.bg-\[var\(--border\)\]{background-color:var(--border)}.bg-\[var\(--primary\)\]{background-color:var(--primary)}.bg-\[var\(--primary-soft\)\]{background-color:var(--primary-soft)}.bg-black\/40{background-color:#0006}.bg-white{--tw-bg-opacity:1;background-color:rgb(255 255 255/var(--tw-bg-opacity,1))}.bg-white\/10{background-color:#ffffff1a}.p-1{padding:.25rem}.p-2{padding:.5rem}.p-3{padding:.75rem}.p-4{padding:1rem}.\!px-2{padding-left:.5rem!important;padding-right:.5rem!important}.\!py-1{padding-top:.25rem!important;padding-bottom:.25rem!important}.px-0\.5{padding-left:.125rem;padding-right:.125rem}.px-1{padding-left:.25rem;padding-right:.25rem}.px-1\.5{padding-left:.375rem;padding-right:.375rem}.px-2{padding-left:.5rem;padding-right:.5rem}.px-3{padding-left:.75rem;padding-right:.75rem}.px-4{padding-left:1rem;padding-right:1rem}.py-0\.5{padding-top:.125rem;padding-bottom:.125rem}.py-1{padding-top:.25rem;padding-bottom:.25rem}.py-1\.5{padding-top:.375rem;padding-bottom:.375rem}.py-10{padding-top:2.5rem;padding-bottom:2.5rem}.py-2{padding-top:.5rem;padding-bottom:.5rem}.py-4{padding-top:1rem;padding-bottom:1rem}.py-6{padding-top:1.5rem;padding-bottom:1.5rem}.py-8{padding-top:2rem;padding-bottom:2rem}.pb-1\.5{padding-bottom:.375rem}.pb-10{padding-bottom:2.5rem}.pb-4{padding-bottom:1rem}.pb-5{padding-bottom:1.25rem}.pb-6{padding-bottom:1.5rem}.pl-\[38px\]{padding-left:38px}.pr-10{padding-right:2.5rem}.pt-1{padding-top:.25rem}.pt-3{padding-top:.75rem}.pt-6{padding-top:1.5rem}.text-left{text-align:left}.text-center{text-align:center}.font-mono{font-family:IBM Plex Mono,ui-monospace,monospace}.text-2xl{font-size:1.5rem;line-height:2rem}.text-\[10px\]{font-size:10px}.text-\[11px\]{font-size:11px}.text-base{font-size:1rem;line-height:1.5rem}.text-lg{font-size:1.125rem;line-height:1.75rem}.text-sm{font-size:.875rem;line-height:1.25rem}.text-xs{font-size:.75rem;line-height:1rem}.font-medium{font-weight:500}.font-semibold{font-weight:600}.lowercase{text-transform:lowercase}.tabular-nums{--tw-numeric-spacing:tabular-nums;font-variant-numeric:var(--tw-ordinal) var(--tw-slashed-zero) var(--tw-numeric-figure) var(--tw-numeric-spacing) var(--tw-numeric-fraction)}.leading-relaxed{line-height:1.625}.tracking-tight{letter-spacing:-.025em}.text-\[var\(--error\)\]{color:var(--error)}.text-\[var\(--primary\)\]{color:var(--primary)}.text-\[var\(--rule\)\]{color:var(--rule)}.text-\[var\(--text\)\]{color:var(--text)}.text-\[var\(--text-faint\)\]{color:var(--text-faint)}.text-\[var\(--text-muted\)\]{color:var(--text-muted)}.text-\[var\(--text-on-dark\)\]{color:var(--text-on-dark)}.text-white{--tw-text-opacity:1;color:rgb(255 255 255/var(--tw-text-opacity,1))}.text-white\/55{color:#ffffff8c}.underline{text-decoration-line:underline}.opacity-0{opacity:0}.opacity-100{opacity:1}.opacity-40{opacity:.4}.shadow{--tw-shadow:0 1px 3px 0 #0000001a, 0 1px 2px -1px #0000001a;--tw-shadow-colored:0 1px 3px 0 var(--tw-shadow-color), 0 1px 2px -1px var(--tw-shadow-color);box-shadow:var(--tw-ring-offset-shadow,0 0 #0000), var(--tw-ring-shadow,0 0 #0000), var(--tw-shadow)}.shadow-lg{--tw-shadow:0 0 #0000;--tw-shadow-colored:0 0 #0000;box-shadow:var(--tw-ring-offset-shadow,0 0 #0000), var(--tw-ring-shadow,0 0 #0000), var(--tw-shadow)}.invert{--tw-invert:invert(100%);filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.filter{filter:var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow)}.transition-\[width\,opacity\]{transition-property:width,opacity;transition-duration:.15s;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-colors{transition-property:color,background-color,border-color,text-decoration-color,fill,stroke;transition-duration:.15s;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-opacity{transition-property:opacity;transition-duration:.15s;transition-timing-function:cubic-bezier(.4,0,.2,1)}.transition-transform{transition-property:transform;transition-duration:.15s;transition-timing-function:cubic-bezier(.4,0,.2,1)}.duration-200{transition-duration:.2s}.ease-out{transition-timing-function:cubic-bezier(0,0,.2,1)}:root{--bg:#f5f6f8;--bg-card:#fff;--bg-hover:#f0f2f5;--bg-elevated:#fff;--border:#e2e5ea;--rule:#c8ced6;--text:#15202b;--text-muted:#4a5a6a;--text-faint:#546274;--text-secondary:#3d4a5c;--bg-header:#1a2332;--bg-header-secondary:#243044;--primary:#3d5a80;--primary-hover:#1a2332;--primary-soft:#3d5a801f;--accent:#1a2332;--accent-light:#3d5a80;--on-primary:#f4f6f8;--error:#8b3a3a;--error-soft:#f5e8eb;--success:#2f6b4f;--success-soft:#e4f0ec;--focus:#3d5a80;--ease-out:cubic-bezier(.22, 1, .36, 1);--dur-fast:.1s;--dur:.16s;--font-display:"Source Sans 3", "Segoe UI", system-ui, sans-serif;--font-body:"Source Sans 3", -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;--font-mono:"Source Code Pro", ui-monospace, "SFMono-Regular", monospace;--font-sans:var(--font-body);--radius:4px;--radius-lg:6px;--radius-sm:3px;--radius-md:5px;--bg-primary:#f5f6f8;--bg-secondary:#fff;--bg-card-hover:#f0f2f5;--bg-input:#f3f4f6;--accent-dim:#3d5a801a;--accent-teal:#2f6f6a;--accent-green:#2f6b4f;--accent-amber:#8a5a2b;--accent-rose:#8b3a3a;--accent-purple:#5c4d7a;--text-primary:#15202b;--text-on-dark:#f4f6f8;--border-hover:#c8ced6;--border-accent:#3d5a80;--path-prodrug:#3d5a80;--path-active-metabolite:#2f6b4f;--path-target:#8b3a3a;--path-enzyme:#8a5a2b;--path-transporter:#5c4d7a;--path-signaling:#6b4570;--path-pathway-node:#2f6f6a;--path-edge:#9aa5b1;--nav-height:56px;--content-max:1240px;--transition-fast:.15s ease;--transition-base:.22s ease;--shadow-sm:0 1px 2px #1a23320a;--shadow-md:0 2px 8px #1a23320f;--shadow-lg:0 8px 24px #1a233214;--z-sticky:100;--z-dropdown:200;--z-modal:300;--lightningcss-light:initial;--lightningcss-dark: ;color-scheme:light}html,html.dark,[data-theme=dark]{--lightningcss-light:initial;--lightningcss-dark: ;color-scheme:light}*,:before,:after{box-sizing:border-box}html{scroll-behavior:smooth;background:var(--bg);overflow-x:clip}body{font-family:var(--font-body);background:var(--bg);color:var(--text);-webkit-font-smoothing:antialiased;min-height:100vh;margin:0;font-size:15px;line-height:1.55;overflow-x:clip}h1,h2,h3,h4{font-family:var(--font-display);letter-spacing:-.01em;color:var(--text);font-style:normal;font-weight:600}a{color:var(--accent-light);text-decoration:none}a:hover{color:var(--accent);text-decoration:underline}:focus:not(:focus-visible){outline:none}:focus-visible{outline:2px solid var(--focus);outline-offset:2px}.skip-link{z-index:1000;border-radius:var(--radius);background:var(--bg-header);color:var(--text-on-dark);padding:.5rem .75rem;position:absolute;top:.5rem;left:-9999px}.skip-link:focus{left:.5rem}.pd-logo{color:inherit;align-items:center;gap:.6rem;text-decoration:none;display:inline-flex}.pd-logo:hover{color:inherit;text-decoration:none}.pd-logo-mark{letter-spacing:.02em;color:#fff;width:30px;height:30px;font-size:.7rem;font-weight:700;font-family:var(--font-mono);background:#ffffff1f;border:1px solid #ffffff29;border-radius:3px;flex-shrink:0;justify-content:center;align-items:center;display:flex}.pd-logo-mark--on-light{background:var(--bg-header);border-color:var(--bg-header);color:#fff}.pd-logo-text{letter-spacing:-.01em;color:inherit;font-size:1.05rem;font-weight:600;line-height:1.2}.pd-logo-text span{opacity:.85;font-weight:400}.sidebar-brand{background:var(--bg-header);color:var(--text-on-dark)}.surface-card,.glass-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg);box-shadow:var(--shadow-sm);-webkit-backdrop-filter:none;backdrop-filter:none;padding:1.25rem 1.5rem}.glow-blue,.glow-green{box-shadow:none!important}::-webkit-scrollbar{width:8px;height:8px}::-webkit-scrollbar-track{background:0 0}::-webkit-scrollbar-thumb{background:var(--rule);border-radius:4px}a,button,input,select,textarea,.surface-card,.glass-card{transition-property:color,background-color,border-color,opacity;transition-duration:var(--dur-fast);transition-timing-function:var(--ease-out)}@media (prefers-reduced-motion:reduce){*,:before,:after{scroll-behavior:auto!important;transition-duration:.01ms!important;animation-duration:.01ms!important;animation-iteration-count:1!important}}@keyframes skeleton-shimmer{0%{background-position:100% 0}to{background-position:-100% 0}}.skeleton-block{border-radius:var(--radius);background:linear-gradient(90deg, var(--bg-hover) 0%, var(--bg-elevated) 45%, var(--bg-hover) 90%);background-size:200% 100%;animation:1.2s ease-in-out infinite skeleton-shimmer;display:block}@media (prefers-reduced-motion:reduce){.skeleton-block{opacity:.65;animation:none}}.sr-only{clip:rect(0,0,0,0);white-space:nowrap;border:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}.form-input{box-sizing:border-box;width:100%;min-height:2.75rem;font-family:var(--font-body);border-radius:var(--radius);border:1px solid var(--border);background:var(--bg-elevated);color:var(--text);margin:0;padding:.625rem .75rem;font-size:.875rem;line-height:1.4;display:block}.form-input.form-input-icon{padding-left:2.5rem}.form-input.form-input-with-toggle{padding-right:2.75rem}.form-field-toggle{border-radius:var(--radius);width:2rem;height:2rem;color:var(--text-faint);cursor:pointer;z-index:1;background:0 0;border:none;justify-content:center;align-items:center;display:inline-flex;position:absolute;top:50%;right:.35rem;transform:translateY(-50%)}.form-field-toggle:hover{color:var(--text);background:var(--bg-hover)}.form-input::placeholder{color:var(--text-faint)}.form-input:focus-visible{border-color:var(--primary);outline:2px solid var(--focus);outline-offset:1px;box-shadow:0 0 0 1px var(--primary)}.form-field{flex-direction:column;gap:.375rem;min-width:0;display:flex}.form-field-label{color:var(--text);font-size:.8125rem;font-weight:600;display:block}.form-field-control{min-width:0;position:relative}.form-field-control>svg.form-field-icon{width:1rem;height:1rem;color:var(--text-faint);pointer-events:none;z-index:1;position:absolute;top:50%;left:.75rem;transform:translateY(-50%)}textarea.form-input{resize:vertical;min-height:8rem;line-height:1.5}.btn-primary{border-radius:var(--radius);background:var(--bg-header);color:var(--on-primary);font-family:var(--font-body);cursor:pointer;border:1px solid #0000;justify-content:center;align-items:center;gap:.5rem;padding:.55rem 1rem;font-size:.875rem;font-weight:600;text-decoration:none;display:inline-flex}.btn-primary:hover:not(:disabled){background:var(--bg-header-secondary);color:var(--on-primary);text-decoration:none}.btn-secondary{border-radius:var(--radius);color:var(--primary);font-family:var(--font-body);border:1px solid var(--border);cursor:pointer;background:0 0;justify-content:center;align-items:center;gap:.5rem;padding:.55rem 1rem;font-size:.875rem;font-weight:600;text-decoration:none;display:inline-flex}.btn-secondary:hover:not(:disabled){background:var(--primary-soft);border-color:var(--primary);color:var(--primary);text-decoration:none}.form-error{border:1px solid color-mix(in srgb, var(--error) 35%, var(--border));background:var(--error-soft);color:var(--error);border-radius:var(--radius);padding:.625rem .75rem;font-size:.8125rem;line-height:1.45}.form-success{border:1px solid color-mix(in srgb, var(--success) 35%, var(--border));background:var(--success-soft);color:var(--success);border-radius:var(--radius);padding:.625rem .75rem;font-size:.8125rem;line-height:1.45}.chip{border:1px solid var(--border);background:var(--blue-100);color:var(--blue-800);border-radius:var(--radius);letter-spacing:.02em;align-items:center;gap:.25rem;padding:.15rem .5rem;font-size:.6875rem;font-weight:600;display:inline-flex}.chip-active{border-color:var(--primary);background:var(--primary-soft);color:var(--primary)}.page-container{width:100%;max-width:none;min-height:0;margin:0;padding:0}.navbar{z-index:var(--z-sticky);height:var(--nav-height);background:var(--bg-header);color:var(--text-on-dark);box-shadow:var(--shadow-sm);border-bottom:1px solid #ffffff0f;justify-content:space-between;align-items:center;padding:0 1.5rem;display:flex;position:sticky;top:0}.navbar-brand{color:var(--text-on-dark);flex-shrink:0;align-items:center;gap:.6rem;text-decoration:none;display:flex}.navbar-brand:hover{color:var(--text-on-dark);text-decoration:none}.navbar-brand .logo-icon{border-radius:var(--radius-sm);letter-spacing:.02em;color:#fff;width:30px;height:30px;font-size:.7rem;font-weight:700;font-family:var(--font-mono);background:#ffffff1f;border:1px solid #ffffff29;justify-content:center;align-items:center;display:flex}.navbar-brand h1{letter-spacing:-.01em;font-size:1.05rem;font-weight:600}.navbar-brand h1 span{opacity:.85;font-weight:400}.navbar-links{align-items:center;gap:.15rem;list-style:none;display:flex}.navbar-links a{border-radius:var(--radius-sm);color:#ffffffc7;transition:background var(--transition-fast), color var(--transition-fast);white-space:nowrap;align-items:center;gap:.35rem;padding:.4rem .7rem;font-size:.82rem;font-weight:500;text-decoration:none;display:flex}.navbar-links a:hover{color:#fff;background:#ffffff1a;text-decoration:none}.navbar-links a.active{color:#fff;background:#ffffff24}.navbar-links .nav-icon{opacity:.9;display:flex}.nav-toggle{color:#fff;cursor:pointer;border-radius:var(--radius-sm);background:0 0;border:none;padding:.35rem;display:none}.nav-toggle:hover{background:#ffffff1a}@media (max-width:960px){.nav-toggle{display:flex}.navbar-links{top:var(--nav-height);background:var(--bg-header);box-shadow:var(--shadow-md);z-index:var(--z-dropdown);border-bottom:1px solid #ffffff14;flex-direction:column;align-items:stretch;padding:.5rem;display:none;position:absolute;left:0;right:0}.navbar-links.open{display:flex}.navbar-links a{padding:.75rem 1rem}}.page-container{max-width:var(--content-max);min-height:calc(100vh - var(--nav-height) - 72px);width:100%;min-width:0;margin:0 auto;padding:1.5rem 1.5rem 3rem;overflow-x:clip}.db-toc{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);flex-wrap:wrap;gap:.35rem;margin:0 0 1.25rem;padding:.65rem .75rem;display:flex;position:static}.db-toc-link{color:var(--text-secondary);background:var(--bg-input);border:1px solid var(--border);white-space:nowrap;border-radius:999px;padding:.2rem .55rem;font-size:.72rem;font-weight:600;text-decoration:none}.db-toc-link:hover{color:var(--accent);border-color:var(--accent-light);background:var(--accent-dim);text-decoration:none}.db-table-block{flex-direction:column;gap:.4rem;min-width:0;max-width:100%;display:flex}.db-table-note{color:var(--text-muted);overflow-wrap:anywhere;margin:0;font-size:.78rem;line-height:1.45}.db-table-meta{color:var(--text-muted);margin:0;font-size:.72rem;font-weight:600}.db-table-block{width:100%;min-width:0}.db-table-note{color:var(--text-muted);margin:0 0 .5rem;font-size:.8rem;line-height:1.45}.db-table-wrap{-webkit-overflow-scrolling:touch;border:1px solid var(--border);border-radius:var(--radius-md);background:var(--bg-card);width:100%;max-width:100%;box-shadow:var(--shadow-sm);overflow-x:auto}.db-data-table{border-collapse:separate;border-spacing:0;table-layout:auto;width:100%;min-width:100%;font-size:.84rem}.db-data-table th{text-align:left;color:var(--text-muted);text-transform:none;letter-spacing:.01em;border-bottom:1px solid var(--border);white-space:normal;vertical-align:bottom;background:#f7f8fa;padding:.55rem .85rem;font-size:.72rem;font-weight:600;line-height:1.3}.db-data-table td{color:var(--text-secondary);vertical-align:top;white-space:normal;overflow-wrap:break-word;word-break:break-word;-webkit-hyphens:auto;hyphens:auto;border-bottom:1px solid #eef1f4;min-width:0;max-width:none;padding:.6rem .85rem;line-height:1.5}.db-data-table td:first-child{color:var(--text-primary);white-space:normal;min-width:6.5rem;max-width:18rem;font-weight:600}.db-data-table td:nth-child(2){color:var(--text-secondary);min-width:0;font-weight:400}.db-data-table.pdt-table{min-width:max(100%,520px)}.db-data-table.pdt-table th,.db-data-table.pdt-table td{white-space:normal;vertical-align:top}.db-data-table.pdt-table td:first-child{width:auto;max-width:12rem}.db-data-table tbody tr:nth-child(2n){background:#fafbfc}.db-data-table tbody tr:hover{background:color-mix(in srgb, var(--primary-soft) 55%, #fff)}.db-data-table tr:last-child td{border-bottom:none}.db-table-link{color:var(--primary);overflow-wrap:break-word;word-break:break-word;white-space:normal;font-weight:600;text-decoration:none;display:inline}.db-table-link:hover{color:var(--primary-hover);text-decoration:underline}.db-data-table.pdt-table th,.db-data-table.pdt-table td,.db-data-table td:last-child{white-space:normal}.db-mv-inline{color:var(--text-primary);overflow-wrap:anywhere;margin:0;font-size:.9rem;line-height:1.65}.db-mv-sep{color:var(--text-faint);-webkit-user-select:none;user-select:none;font-weight:500}.db-mv-codes{flex-wrap:wrap;gap:.3rem .4rem;max-width:100%;margin:0;display:flex}.db-mv-code{font-family:var(--font-mono);letter-spacing:.01em;color:#243044;background:var(--primary-soft);border-radius:var(--radius-sm);padding:.15rem .45rem;font-size:.75rem;font-weight:500;line-height:1.35}.db-mv-tags{flex-wrap:wrap;align-items:center;gap:.35rem .4rem;max-width:100%;margin:0;display:flex}.db-mv-tag{color:var(--text-secondary);background:var(--bg-hover);overflow-wrap:anywhere;word-break:break-word;border-radius:999px;max-width:100%;padding:.2rem .55rem;font-size:.8rem;line-height:1.4}.db-mv-count{color:var(--text-faint);margin-left:.15rem;font-size:.72rem;font-weight:600}.db-chip-row{flex-wrap:wrap;gap:.35rem;min-width:0;max-width:100%;margin-top:.1rem;display:flex}.db-chip{background:var(--bg-hover);color:var(--text-secondary);overflow-wrap:anywhere;word-break:break-word;white-space:normal;border:none;border-radius:999px;max-width:100%;padding:.18rem .5rem;font-size:.78rem;display:inline-block}.db-prose{flex-direction:column;gap:.55rem;display:flex}.db-prose p,.db-prose-single,.db-text{overflow-wrap:anywhere;word-break:break-word;max-width:100%;margin:0;line-height:1.6}.db-pre{white-space:pre-wrap;word-break:break-word;font-size:.78rem;line-height:1.5;font-family:var(--font-mono,ui-monospace, monospace);max-height:28rem;margin:0;overflow:auto}.detail-section{scroll-margin-top:calc(var(--nav-height) + 5.5rem)}.page-header{margin-bottom:1.35rem}.page-header h2{color:var(--text-primary);letter-spacing:-.015em;text-wrap:balance;margin-bottom:.25rem;font-size:1.45rem;font-style:normal;font-weight:600}.page-header .subtitle{color:var(--text-secondary);max-width:68ch;font-size:.92rem;line-height:1.55}.page-header .count-badge{background:var(--accent-dim);color:var(--accent);vertical-align:middle;border-radius:999px;align-items:center;margin-left:.5rem;padding:.15rem .55rem;font-size:.75rem;font-weight:600;display:inline-flex}.card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);box-shadow:var(--shadow-sm);overflow-wrap:anywhere;word-break:break-word;min-width:0;max-width:100%;padding:1.15rem 1.25rem}.btn-primary,.btn-secondary{border-radius:var(--radius-sm);font-size:.875rem;font-weight:600;font-family:var(--font-sans);cursor:pointer;transition:background var(--transition-fast), border-color var(--transition-fast), color var(--transition-fast);border:1px solid #0000;justify-content:center;align-items:center;gap:.45rem;padding:.55rem 1.1rem;line-height:1.2;text-decoration:none;display:inline-flex}.btn-primary{background:var(--accent);color:#fff;border-color:var(--accent)}.btn-primary:hover{background:var(--accent-light);border-color:var(--accent-light);color:#fff;text-decoration:none}.btn-primary:disabled{opacity:.5;cursor:not-allowed}.btn-secondary{background:var(--bg-secondary);color:var(--text-primary);border-color:var(--border)}.btn-secondary:hover{background:var(--bg-card-hover);border-color:var(--border-hover);color:var(--text-primary);text-decoration:none}.table-toolbar{flex-wrap:wrap;align-items:center;gap:.75rem;margin-bottom:1rem;display:flex}.group-filter-bar{background:var(--bg-input,#f8fafc);border:1px solid var(--border);border-radius:var(--radius-sm);flex-wrap:wrap;gap:.45rem;margin-bottom:.85rem;padding:.55rem .65rem;display:flex}.group-filter-btn{border:1px solid var(--border);background:var(--bg-card);color:var(--text-secondary);font-size:.78rem;font-weight:500;font-family:var(--font-sans);cursor:pointer;transition:background var(--transition-fast), border-color var(--transition-fast), color var(--transition-fast), box-shadow var(--transition-fast);white-space:nowrap;border-radius:999px;align-items:center;gap:.4rem;padding:.35rem .75rem;display:inline-flex}.group-filter-btn:hover{border-color:var(--accent-light,#93c5fd);color:var(--accent,#1d4ed8);background:var(--accent-dim,#eff6ff)}.group-filter-btn.active{background:var(--accent,#1d4ed8);border-color:var(--accent,#1d4ed8);color:#fff;box-shadow:0 1px 2px #1d4ed840}.group-filter-btn.active .group-filter-count{color:#fff;background:#ffffff38}.group-filter-count{font-variant-numeric:tabular-nums;background:var(--bg-input,#e2e8f0);min-width:1.35rem;color:var(--text-muted,#64748b);border-radius:999px;justify-content:center;align-items:center;padding:.05rem .35rem;font-size:.7rem;font-weight:600;display:inline-flex}.group-filter-btn.group-filter-approved.active{background:#059669;border-color:#059669}.group-filter-btn.group-filter-investigational.active{background:#7c3aed;border-color:#7c3aed}.group-filter-btn.group-filter-experimental.active{background:#d97706;border-color:#d97706}.group-filter-btn.group-filter-withdrawn.active{background:#dc2626;border-color:#dc2626}.group-filter-btn.group-filter-illicit.active{background:#991b1b;border-color:#991b1b}.group-filter-btn.group-filter-vet_approved.active{background:#0d9488;border-color:#0d9488}.group-filter-btn.group-filter-nutraceutical.active{background:#16a34a;border-color:#16a34a}.search-box{flex:1;min-width:200px;max-width:380px;position:relative}.search-box input,.form-group input,.form-group select,.per-page-select{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-sm);width:100%;min-height:40px;color:var(--text-primary);font-size:.875rem;font-family:var(--font-sans);transition:border-color var(--transition-fast), box-shadow var(--transition-fast);padding:.5rem .75rem}.search-box input{padding-left:2.2rem}.search-box input:focus-visible,.form-group input:focus-visible,.form-group select:focus-visible,.per-page-select:focus-visible{border-color:var(--accent-light);outline:2px solid var(--focus);outline-offset:1px;box-shadow:0 0 0 3px var(--accent-dim)}.search-box input::-moz-placeholder{color:var(--text-muted)}.form-group input::-moz-placeholder{color:var(--text-muted)}.search-box input::placeholder,.form-group input::placeholder{color:var(--text-muted)}.search-box .search-icon{color:var(--text-muted);pointer-events:none;display:flex;position:absolute;top:50%;left:.7rem;transform:translateY(-50%)}.per-page-select{cursor:pointer;width:auto;min-width:110px;color:var(--text-secondary);font-size:.82rem}.view-toggle{border:1px solid var(--border);border-radius:var(--radius-sm);background:var(--bg-card);display:inline-flex;overflow:hidden}.view-toggle button{cursor:pointer;color:var(--text-muted);font-size:.8rem;font-weight:500;font-family:var(--font-sans);background:0 0;border:none;padding:.45rem .7rem}.view-toggle button.active{background:var(--accent-dim);color:var(--accent)}.compound-grid{grid-template-columns:repeat(auto-fill,minmax(240px,1fr));gap:.9rem;display:grid}.compound-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);min-width:0;transition:border-color var(--transition-base), box-shadow var(--transition-base);color:inherit;text-decoration:none;display:block;overflow:hidden}.compound-card:hover{border-color:var(--accent-light);box-shadow:var(--shadow-md);color:inherit;text-decoration:none}.compound-card .structure-img{border-bottom:1px solid var(--border);background:#fafbfc;justify-content:center;align-items:center;width:100%;height:170px;padding:.5rem;display:flex}.cc-body{min-width:0;padding:.85rem .95rem 1rem;overflow:hidden}.cc-name{color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;margin-bottom:.2rem;font-size:.92rem;font-weight:600;line-height:1.3}.cc-props{flex-direction:column;gap:.2rem;min-width:0;margin-top:.45rem;display:flex}.cc-prop{color:var(--text-muted);font-size:.75rem;font-family:var(--font-mono);overflow-wrap:anywhere;word-break:break-word;max-width:100%}.cc-badges{flex-wrap:wrap;gap:.3rem;min-width:0;margin-top:.55rem;display:flex}.table-wrapper{border:1px solid var(--border);border-radius:var(--radius-md);background:var(--bg-card);overflow-x:auto}.data-table{border-collapse:collapse;width:100%;font-size:.84rem}.data-table th{text-align:left;background:var(--bg-input);color:var(--text-secondary);text-transform:uppercase;letter-spacing:.03em;border-bottom:1px solid var(--border);white-space:nowrap;cursor:pointer;-webkit-user-select:none;user-select:none;padding:.7rem .85rem;font-size:.75rem;font-weight:600;position:sticky;top:0}.data-table th:hover{color:var(--accent)}.data-table td{border-bottom:1px solid var(--border);color:var(--text-secondary);vertical-align:top;overflow-wrap:anywhere;word-break:break-word;max-width:28rem;padding:.65rem .85rem}.data-table tr:last-child td{border-bottom:none}.data-table tr:hover td{background:var(--bg-card-hover)}.cell-name{color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;font-weight:600}.cell-id{font-family:var(--font-mono);color:var(--accent-light);overflow-wrap:anywhere;word-break:break-word;max-width:12rem;font-size:.78rem}.sort-indicator{opacity:.6;margin-left:.25rem}.cell-badge,.badge-default,.badge-approved,.badge-experimental,.badge-investigational,.badge-withdrawn,.badge-confirmed,.badge-seed{white-space:normal;overflow-wrap:anywhere;word-break:break-word;text-wrap:balance;border:1px solid #0000;border-radius:999px;align-items:center;max-width:100%;padding:.12rem .45rem;font-size:.7rem;font-weight:600;line-height:1.4;display:inline-flex}.badge-default{color:#475569;background:#f1f5f9;border-color:#e2e8f0}.badge-approved{color:#2f6b4f;background:#e8f2ec;border-color:#c5ddd0}.badge-experimental{color:#8a5a2b;background:#f5eee6;border-color:#e2d2bf}.badge-investigational{color:#3d5a80;background:#eef1f5;border-color:#d0d8e4}.badge-withdrawn{color:#8b3a3a;background:#f5eaea;border-color:#e0c8c8}.badge-confirmed{color:#1a2332;background:#eef1f5;border-color:#d0d8e4}.badge-seed{color:#5c4d7a;background:#f1eef4;border-color:#d8d2e2}.mech-page .cell-badge,.mech-page .badge-default,.mech-page .badge-approved,.mech-page .badge-experimental,.mech-page .badge-investigational,.mech-page .badge-withdrawn,.mech-page .badge-confirmed,.mech-page .badge-seed{background:var(--primary-soft);color:var(--bg-header);border-color:var(--border)}.pagination{flex-wrap:wrap;justify-content:space-between;align-items:center;gap:1rem;margin-top:1.25rem;display:flex}.pagination-info{color:var(--text-muted);font-size:.82rem}.pagination-controls{flex-wrap:wrap;gap:.25rem;display:flex}.pagination-controls button{border:1px solid var(--border);background:var(--bg-card);border-radius:var(--radius-sm);min-width:34px;height:34px;color:var(--text-secondary);font-size:.8rem;font-family:var(--font-sans);cursor:pointer}.pagination-controls button:hover:not(:disabled){border-color:var(--accent-light);color:var(--accent)}.pagination-controls button.active{background:var(--accent);border-color:var(--accent);color:#fff}.pagination-controls button:disabled{opacity:.4;cursor:not-allowed}.hero{background:var(--bg-secondary);border:1px solid var(--border);border-radius:var(--radius-lg);box-shadow:var(--shadow-sm);margin-bottom:1.5rem;padding:2rem 2.1rem 1.75rem}.hero h2{font-family:var(--font-display);letter-spacing:-.02em;color:var(--text);margin-bottom:.5rem;font-size:1.75rem;font-style:normal;font-weight:600}.hero-subtitle{color:var(--text-secondary);max-width:62ch;margin-bottom:1.25rem;font-size:1rem;line-height:1.6}.hero-actions{flex-wrap:wrap;gap:.6rem;margin-bottom:1.5rem;display:flex}.hero-stats{border-top:1px solid var(--border);grid-template-columns:repeat(auto-fit,minmax(120px,1fr));gap:.75rem;padding-top:1.25rem;display:grid}.hero-stat{padding:.35rem 0}.hs-value{color:var(--text-primary);font-variant-numeric:tabular-nums;letter-spacing:-.02em;font-size:1.45rem;font-weight:600}.hs-label{color:var(--text-muted);margin-top:.1rem;font-size:.75rem;font-weight:500}.features-grid{grid-template-columns:repeat(auto-fill,minmax(260px,1fr));gap:.85rem;display:grid}.feature-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);color:inherit;transition:border-color var(--transition-base), box-shadow var(--transition-base);padding:1.1rem 1.15rem;text-decoration:none;display:block}.feature-card:hover{border-color:var(--accent-light);box-shadow:var(--shadow-md);color:inherit;text-decoration:none}.fc-icon{border-radius:var(--radius-sm);background:var(--accent-dim);width:36px;height:36px;color:var(--accent);justify-content:center;align-items:center;margin-bottom:.7rem;display:flex}.feature-card h3{color:var(--text-primary);margin-bottom:.35rem;font-size:.95rem;font-style:normal;font-weight:600}.feature-card p{color:var(--text-secondary);font-size:.84rem;line-height:1.5}.back-link{color:var(--text-muted);align-items:center;gap:.3rem;margin-bottom:1rem;font-size:.85rem;font-weight:500;text-decoration:none;display:inline-flex}.back-link:hover{color:var(--accent)}.detail-header{align-items:flex-start;gap:1rem;margin-bottom:1.25rem;display:flex}.drug-icon{border-radius:var(--radius-md);background:var(--accent-dim);width:48px;height:48px;color:var(--accent);flex-shrink:0;justify-content:center;align-items:center;display:flex}.drug-meta{flex:1;min-width:0}.drug-meta h2{letter-spacing:-.015em;overflow-wrap:anywhere;word-break:break-word;margin-bottom:.2rem;font-size:1.45rem;font-style:normal;font-weight:600}.drug-id{font-family:var(--font-mono);color:var(--accent-light);overflow-wrap:anywhere;word-break:break-word;margin-bottom:.45rem;font-size:.85rem}.drug-badges{flex-wrap:wrap;gap:.35rem;min-width:0;display:flex}.detail-structure-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);flex-direction:column;align-items:center;margin-bottom:1.25rem;padding:1rem;display:flex}.struct-caption{color:var(--text-secondary);font-size:.8rem;font-family:var(--font-mono);margin-top:.65rem}.detail-description{color:var(--text-secondary);text-wrap:pretty;overflow-wrap:anywhere;word-break:break-word;max-width:100%;font-size:.92rem;line-height:1.65}.detail-grid{flex-direction:column;gap:.75rem;min-width:0;display:flex}.detail-section{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);min-width:0;overflow:visible}.detail-section .section-body{overflow:auto visible}.section-header{cursor:pointer;-webkit-user-select:none;user-select:none;background:var(--bg-card);text-align:left;width:100%;min-width:0;min-height:44px;font:inherit;color:inherit;border:none;border-bottom:1px solid #0000;align-items:center;gap:.6rem;margin:0;padding:.9rem 1.05rem;display:flex}.section-header:hover{background:var(--bg-card-hover)}.section-header:focus-visible{outline:2px solid var(--focus);outline-offset:-2px;z-index:1;position:relative}.section-header .section-title,.section-header h3{min-width:0;color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;text-wrap:balance;flex:1;font-size:.95rem;font-style:normal;font-weight:600;line-height:1.3}.section-icon{color:var(--text-muted);flex-shrink:0;display:flex}.chevron{color:var(--text-muted);transition:transform var(--transition-fast);flex-shrink:0;font-size:.85rem}.chevron.open{transform:rotate(180deg)}.section-body{border-top:1px solid var(--border);min-width:0;padding:.35rem 1.05rem 1rem;overflow-x:clip}.section-body.collapsed,.section-body[hidden]{border-top:none;padding:0;display:none}.detail-section+.detail-section{margin-top:.65rem}.info-row{border-bottom:1px solid #eef1f4;grid-template-columns:minmax(100px,170px) minmax(0,1fr);align-items:start;gap:.85rem 1rem;min-width:0;padding:.7rem 0;display:grid}.info-row:last-child{border-bottom:none}.info-label{color:var(--text-muted);overflow-wrap:anywhere;word-break:break-word;min-width:0;padding-top:.1rem;font-size:.78rem;font-weight:600}.info-value{color:var(--text-secondary);overflow-wrap:anywhere;word-break:break-word;min-width:0;max-width:100%;font-size:.88rem;line-height:1.55}.info-value a{overflow-wrap:anywhere;word-break:break-word}.ext-links-table-wrap{width:100%;max-width:100%;padding-top:.5rem;overflow-x:auto}.ext-links-table{border-collapse:collapse;width:100%;font-size:.88rem}.ext-links-table th{text-align:left;background:var(--bg-input);color:var(--text-secondary);text-transform:uppercase;letter-spacing:.03em;border-bottom:1px solid var(--border);padding:.5rem .75rem;font-size:.72rem;font-weight:700}.ext-links-table td{vertical-align:top;overflow-wrap:anywhere;word-break:break-word;border-bottom:1px solid #f1f5f9;padding:.5rem .75rem}.ext-links-table tr:last-child td{border-bottom:none}.ext-db-name{width:40%;max-width:16rem;color:var(--text-primary);font-weight:600}.ext-db-id{font-family:var(--font-mono);color:var(--text-secondary);font-size:.84rem}.ext-id-link{color:#2563eb;overflow-wrap:anywhere;word-break:break-word;font-weight:600;text-decoration:none}.ext-id-link:hover{color:#1d4ed8;text-decoration:underline}.search-form{grid-template-columns:repeat(auto-fill,minmax(220px,1fr));gap:.9rem;display:grid}.form-group label{color:var(--text-secondary);margin-bottom:.35rem;font-size:.78rem;font-weight:600;display:block}.form-actions{flex-wrap:wrap;gap:.55rem;margin-top:1rem;display:flex}.stats-grid{grid-template-columns:repeat(auto-fill,minmax(150px,1fr));gap:.75rem;margin-bottom:1.5rem;display:grid}.stat-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);text-align:left;padding:1rem}.stat-icon{border-radius:var(--radius-sm);background:var(--accent-dim);width:32px;height:32px;color:var(--accent);justify-content:center;align-items:center;margin-bottom:.55rem;display:flex}.stat-value{color:var(--text-primary);font-variant-numeric:tabular-nums;font-size:1.35rem;font-weight:600}.stat-label{color:var(--text-muted);margin-top:.15rem;font-size:.75rem}.bar-chart{flex-direction:column;gap:.55rem;display:flex}.bar-item{grid-template-columns:minmax(80px,160px) 1fr 48px;align-items:center;gap:.65rem;display:grid}.bar-label{color:var(--text-secondary);text-overflow:ellipsis;white-space:nowrap;font-size:.78rem;overflow:hidden}.bar-track{background:var(--bg-input);border-radius:999px;height:8px;overflow:hidden}.bar-fill{background:var(--accent-light);border-radius:999px;min-width:2px;height:100%}.bar-count{color:var(--text-muted);text-align:right;font-variant-numeric:tabular-nums;font-size:.78rem;font-weight:600}.pathways-grid{grid-template-columns:repeat(auto-fill,minmax(280px,1fr));gap:.75rem;display:grid}.pathway-drug-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);color:inherit;min-width:0;transition:border-color var(--transition-fast);padding:0;text-decoration:none;display:block;overflow:hidden}.pathway-drug-card:hover{border-color:var(--accent-light);color:inherit;text-decoration:none}.mech-page{flex-direction:column;gap:0;display:flex}.mech-summary,.mech-jump{flex-wrap:wrap;gap:.4rem;margin:1rem 0 1.5rem;display:flex}.mech-jump{margin:.75rem 0 1.25rem}.mech-chip{color:var(--text-secondary);background:var(--bg-hover);border:1px solid var(--border);border-radius:999px;align-items:center;gap:.35rem;padding:.28rem .7rem;font-size:.75rem;font-weight:600;text-decoration:none;display:inline-flex}.mech-chip:hover{border-color:var(--accent-light);color:var(--bg-header);background:var(--primary-soft);text-decoration:none}.mech-chip--solid{background:var(--bg-header);color:var(--text-on-dark);border-color:var(--bg-header)}.mech-chip--solid:hover{background:var(--bg-header-secondary);color:var(--text-on-dark);border-color:var(--bg-header-secondary)}.mech-chip-count{font-variant-numeric:tabular-nums;color:var(--bg-header);border:1px solid var(--border);background:#fff;border-radius:999px;padding:0 .4rem;font-size:.7rem;font-weight:700;line-height:1.4}.mech-chip--solid .mech-chip-count{color:var(--bg-header)}.mech-section{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);justify-content:space-between;align-items:flex-start;gap:1rem;margin-top:.5rem;padding:.85rem 1.1rem;scroll-margin-top:4rem;display:flex}.mech-section-title{color:var(--bg-header);letter-spacing:-.01em;margin:0;font-size:1.05rem;font-weight:700}.mech-section-sub{color:var(--text-muted);max-width:52rem;margin:.2rem 0 0;font-size:.8rem;line-height:1.45}.mech-count{font-variant-numeric:tabular-nums;color:var(--text-on-dark);background:var(--bg-header);white-space:nowrap;border-radius:999px;flex-shrink:0;padding:.15rem .55rem;font-size:.72rem;font-weight:700}.mech-count--lg{padding:.3rem .7rem;font-size:.78rem}.mech-subgroup{margin-bottom:2rem}.mech-subgroup-head{background:var(--bg-hover);border:1px solid var(--border);border-radius:var(--radius-sm);align-items:center;gap:.5rem;margin-bottom:.35rem;padding:.45rem .85rem;display:flex}.mech-subgroup-title{color:var(--text);margin:0;font-size:.9rem;font-weight:700}.mech-subgroup-desc{color:var(--text-muted);margin:0 0 .75rem;padding-left:.15rem;font-size:.8rem;line-height:1.45}.mech-grid{margin:.85rem 0 2.5rem}.mech-card-bar{background:var(--bg-header);height:3px}.mech-card-body{padding:.9rem 1rem}.mech-card-top{justify-content:space-between;align-items:flex-start;gap:.5rem;margin-bottom:.4rem;display:flex}.mech-card-name{color:var(--text-primary);font-size:.9rem;font-weight:700;line-height:1.3}.mech-card-id{font-family:var(--font-mono);color:var(--text-muted);flex-shrink:0;font-size:.68rem}.mech-card-tags{flex-wrap:wrap;gap:.3rem;margin-bottom:.45rem;display:flex}.mech-tag{background:var(--primary-soft);color:var(--accent-light);border:1px solid var(--border);border-radius:999px;padding:.1rem .45rem;font-size:.65rem;font-weight:600;display:inline-flex}.mech-card-class{color:var(--text-muted);text-overflow:ellipsis;white-space:nowrap;margin:0 0 .4rem;font-size:.72rem;overflow:hidden}.mech-card-moa{color:var(--text-secondary);margin:0 0 .5rem;font-size:.76rem;line-height:1.55}.mech-card-more{color:var(--accent-light);align-items:center;gap:.2rem;font-size:.73rem;font-weight:600;display:inline-flex}.pathway-drug-card .odc-name,.pathway-drug-card .odc-id,.pathway-drug-card .odc-class{overflow-wrap:anywhere;word-break:break-word;max-width:100%}.section-pill{border:1px solid var(--border);background:var(--bg-card);color:var(--text-secondary);border-radius:999px;align-items:center;gap:.35rem;padding:.35rem .7rem;font-size:.78rem;font-weight:600;text-decoration:none;display:inline-flex}.section-pill:hover{border-color:var(--accent-light);color:var(--accent);text-decoration:none}.pathway-panel{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);box-shadow:var(--shadow-sm);margin-bottom:1.25rem;overflow:hidden}.pathway-panel-header{border-bottom:1px solid var(--border);background:linear-gradient(#f8fafc 0%,#fff 100%);flex-wrap:wrap;justify-content:space-between;align-items:center;gap:.75rem;padding:.9rem 1rem;display:flex}.pathway-panel-header h3{color:var(--text-primary);align-items:center;gap:.4rem;font-size:.95rem;font-style:normal;font-weight:600;display:flex}.pathway-panel-meta{color:var(--text-muted);flex-wrap:wrap;align-items:center;gap:.45rem .75rem;font-size:.75rem;display:flex}.pathway-tabs{flex-wrap:wrap;gap:.3rem;padding:.65rem 1rem 0;display:flex}.pathway-tab{border:1px solid var(--border);background:var(--bg-card);color:var(--text-secondary);font-size:.78rem;font-weight:600;font-family:var(--font-sans);border-radius:var(--radius-sm);cursor:pointer;padding:.42rem .8rem}.pathway-tab.active{background:var(--accent);border-color:var(--accent);color:#fff}.pathway-tab:disabled{opacity:.4;cursor:not-allowed}.pathway-body{padding:1rem}.pathway-legend,.pathway-filters{color:var(--text-secondary);flex-wrap:wrap;align-items:center;gap:.55rem .9rem;margin-bottom:.75rem;font-size:.75rem;display:flex}.pathway-filters{background:var(--bg-input);border:1px solid var(--border);border-radius:var(--radius-sm);padding:.55rem .7rem}.pathway-filters-label{color:var(--text-muted);font-weight:600}.pathway-filter-chip{cursor:pointer;-webkit-user-select:none;user-select:none;align-items:center;gap:.3rem;display:inline-flex}.pathway-legend-item{align-items:center;gap:.35rem;display:inline-flex}.pathway-dot{border-radius:50%;flex-shrink:0;width:10px;height:10px}.pathway-network-wrap{border:1px solid var(--border);border-radius:var(--radius-sm);background:radial-gradient(circle at 20% 20%,#1d4ed80a,#0000 45%),radial-gradient(circle at 80% 70%,#0f766e0d,#0000 40%),#f8fafc;width:100%;height:min(560px,72vh);position:relative;overflow:hidden}.pathway-network-wrap svg{width:100%;height:100%;display:block}.pathway-zoom-controls{z-index:2;gap:4px;display:flex;position:absolute;top:10px;right:10px}.pathway-zoom-controls button{border:1px solid var(--border);background:var(--bg-card);border-radius:var(--radius-sm);cursor:pointer;width:30px;height:30px;color:var(--text-secondary);box-shadow:var(--shadow-sm);justify-content:center;align-items:center;display:flex}.pathway-zoom-controls button:hover{border-color:var(--accent-light);color:var(--accent-light)}.pathway-tooltip{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-sm);box-shadow:var(--shadow-md);z-index:2;max-width:280px;color:var(--text-secondary);padding:.5rem .7rem;font-size:.78rem;position:absolute;bottom:28px;left:12px}.pathway-tooltip strong{color:var(--text-primary)}.pathway-tooltip-meta{color:var(--text-muted);margin-top:.2rem;font-size:.7rem}.pathway-layer-hint{color:var(--text-muted);pointer-events:none;max-width:70%;font-size:.65rem;position:absolute;bottom:8px;left:12px}.pathway-conversion{border:1px solid var(--border);border-radius:var(--radius-sm);background:#f8fafc;padding:1.25rem 1rem}.pathway-conversion-flow{flex-wrap:wrap;justify-content:center;align-items:center;gap:.75rem;display:flex}.pathway-conv-node{border-radius:var(--radius-md);border:2px solid var(--border);background:var(--bg-card);text-align:center;min-width:140px;max-width:220px;padding:.85rem 1rem}.pathway-conv-node.prodrug{border-color:var(--path-prodrug);background:#1d4ed80f}.pathway-conv-node.metabolite{border-color:var(--path-active-metabolite);background:#15803d0f}.pathway-conv-role{text-transform:uppercase;letter-spacing:.04em;color:var(--text-muted);margin-bottom:.25rem;font-size:.68rem;font-weight:700;display:block}.pathway-conv-name{color:var(--text-primary);word-break:break-word;font-size:.92rem;font-weight:600}.pathway-conv-arrow{min-width:88px;color:var(--text-muted);flex-direction:column;align-items:center;gap:.25rem;font-size:.7rem;font-weight:600;display:flex}.pathway-conv-line{background:var(--border-hover);width:72px;height:2px;position:relative}.pathway-conv-line:after{content:"";border:5px solid #0000;border-left-color:var(--border-hover);position:absolute;top:-4px;right:-1px}.pathway-conversion-extras{border-top:1px dashed var(--border);margin-top:1.1rem;padding-top:.9rem}.pathway-chip-row{flex-wrap:wrap;gap:.4rem;display:flex}.pathway-chip{border-radius:var(--radius-sm);border:1px solid var(--border);background:var(--bg-card);color:var(--text-primary);flex-direction:column;gap:.1rem;padding:.4rem .55rem;font-size:.78rem;font-weight:600;display:inline-flex}.pathway-chip em{color:var(--text-muted);font-size:.65rem;font-style:normal;font-weight:500}.pathway-kegg-img{border:1px solid var(--border);border-radius:var(--radius-sm);background:var(--bg-card);max-width:100%;height:auto;margin:0 auto;display:block}.pathway-attr{color:var(--text-muted);margin-top:.75rem;font-size:.72rem;line-height:1.45}.pathway-table{border-collapse:collapse;width:100%;font-size:.8rem}.pathway-table th,.pathway-table td{text-align:left;border-bottom:1px solid var(--border);padding:.45rem .55rem}.pathway-table th{background:var(--bg-input);text-transform:uppercase;letter-spacing:.03em;color:var(--text-muted);font-size:.72rem}.pathway-empty{text-align:center;color:var(--text-muted);padding:1.5rem;font-size:.9rem}.pathway-stat-row{flex-wrap:wrap;gap:.4rem;margin-bottom:.75rem;display:flex}.pathway-stat-chip{background:var(--bg-input);border:1px solid var(--border);color:var(--text-secondary);border-radius:999px;align-items:center;gap:.3rem;padding:.28rem .55rem;font-size:.72rem;display:inline-flex}.pathway-split{grid-template-columns:1fr;gap:.75rem;display:grid}.pathway-split.with-table{grid-template-columns:minmax(0,1.4fr) minmax(240px,.9fr)}.pathway-node-table{max-height:min(560px,72vh)}.detail-top{grid-template-columns:minmax(220px,300px) minmax(0,1fr);align-items:start;gap:1rem;min-width:0;margin-bottom:1.25rem;display:grid}.detail-quick-grid{grid-template-columns:repeat(auto-fill,minmax(min(100%,140px),1fr));gap:.55rem;min-width:0;display:grid}.detail-quick-item{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-sm);min-width:0;padding:.65rem .75rem;overflow:hidden}.detail-quick-item .qk-label{text-transform:uppercase;letter-spacing:.04em;color:var(--text-muted);overflow-wrap:anywhere;word-break:break-word;margin-bottom:.2rem;font-size:.68rem;font-weight:700}.detail-quick-item .qk-value{color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;font-size:.86rem;font-weight:600;font-family:var(--font-mono);max-width:100%}.detail-quick-item .qk-value.plain{font-family:var(--font-sans);color:var(--text-secondary);font-size:.82rem;font-weight:500}.featured-pathways{margin-top:1.75rem}.featured-pathways h3{margin-bottom:.35rem;font-size:1.05rem;font-style:normal;font-weight:600}.featured-pathways .section-sub{color:var(--text-secondary);max-width:70ch;margin-bottom:.9rem;font-size:.88rem}.featured-grid{grid-template-columns:repeat(auto-fill,minmax(250px,1fr));gap:.75rem;display:grid}.featured-card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);color:inherit;transition:border-color var(--transition-fast), box-shadow var(--transition-fast);flex-direction:column;gap:.45rem;min-width:0;min-height:140px;padding:1rem;text-decoration:none;display:flex;overflow:hidden}.featured-card:hover{border-color:var(--accent-light);box-shadow:var(--shadow-md);color:inherit;text-decoration:none}.featured-card .fc-top{justify-content:space-between;align-items:flex-start;gap:.5rem;min-width:0;display:flex}.featured-card .fc-name{color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;min-width:0;font-size:.95rem;font-weight:600}.featured-card .fc-meta{color:var(--text-muted);font-size:.75rem;font-family:var(--font-mono);overflow-wrap:anywhere;word-break:break-word}.featured-card .fc-bars{flex-wrap:wrap;gap:.35rem;margin-top:auto;display:flex}.featured-card .fc-bar{background:var(--bg-input);color:var(--text-secondary);border:1px solid var(--border);border-radius:999px;padding:.15rem .45rem;font-size:.7rem;font-weight:600}@media (max-width:800px){.detail-top,.pathway-split.with-table{grid-template-columns:1fr}}.empty-state{text-align:center;color:var(--text-muted);padding:2.5rem 1rem}.empty-icon{opacity:.5;margin-bottom:.75rem}.footer{display:none}.footer p{color:var(--text-muted);max-width:720px;margin:0 auto;font-size:.78rem;line-height:1.55}.footer a{color:var(--accent-light)}.body-explorer-page{flex-direction:column;gap:.9rem;display:flex}.body-explorer-title-row{flex-wrap:wrap;justify-content:space-between;align-items:flex-start;gap:1rem;display:flex}.body-explorer-title{letter-spacing:-.015em;font-size:1.45rem;font-weight:600}.body-explorer-subtitle{color:var(--text-secondary);max-width:62ch;margin-top:.2rem;font-size:.9rem}.body-explorer-stats{flex-wrap:wrap;gap:.4rem;display:flex}.body-stat-pill{border:1px solid var(--border);background:var(--bg-card);color:var(--text-secondary);border-radius:999px;align-items:center;gap:.35rem;padding:.35rem .65rem;font-size:.75rem;font-weight:600;display:inline-flex}.body-layer-tabs{flex-wrap:wrap;gap:.4rem;padding-bottom:.15rem;display:flex;overflow-x:auto}.body-layer-caption{color:var(--text-muted);margin:-.25rem 0 .15rem;font-size:.8rem}.body-layer-caption strong{color:var(--text-secondary);font-weight:600}.body-layer-tab{border:1px solid var(--border);background:var(--bg-card);border-radius:var(--radius-sm);color:var(--text-secondary);cursor:pointer;font-size:.82rem;font-weight:600;font-family:var(--font-sans);align-items:center;gap:.4rem;padding:.5rem .85rem;display:inline-flex}.body-layer-tab em{background:var(--bg-input);color:var(--text-muted);border-radius:999px;padding:.05rem .4rem;font-size:.72rem;font-style:normal}.body-layer-tab.active{background:var(--accent);border-color:var(--accent);color:#fff}.body-layer-tab.active em{color:#fff;background:#ffffff29}.body-explorer-workspace{grid-template-columns:minmax(220px,280px) minmax(0,1.4fr) minmax(260px,340px);align-items:stretch;gap:.85rem;height:min(720px,100vh - 230px);min-height:520px;max-height:780px;display:grid;overflow:hidden}.body-system-rail{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);flex-direction:column;min-height:0;max-height:100%;display:flex;overflow:hidden}.body-rail-search{border-bottom:1px solid var(--border);color:var(--text-muted);align-items:center;gap:.45rem;padding:.65rem .75rem;display:flex}.body-rail-search input{width:100%;font-size:.84rem;font-family:var(--font-sans);color:var(--text-primary);background:0 0;border:none;outline:none}.body-rail-hint{color:var(--text-muted);padding:.5rem .75rem .25rem;font-size:.72rem}.body-system-list{flex:auto;min-height:0;max-height:none;padding:.4rem;list-style:none;overflow:hidden auto}.body-system-item{text-align:left;border-radius:var(--radius-sm);cursor:pointer;width:100%;font-family:var(--font-sans);background:0 0;border:1px solid #0000;grid-template-columns:10px 1fr auto;align-items:start;gap:.55rem;padding:.55rem .5rem;display:grid}.body-system-item:hover{background:var(--bg-card-hover)}.body-system-item.active{background:var(--accent-dim);border-color:var(--border)}.body-system-dot{border-radius:50%;width:8px;height:8px;margin-top:.35rem}.body-system-text{flex-direction:column;gap:.12rem;min-width:0;display:flex}.body-system-text strong{color:var(--text-primary);font-size:.82rem;font-weight:600}.body-system-text small{color:var(--text-muted);-webkit-line-clamp:2;-webkit-box-orient:vertical;font-size:.7rem;line-height:1.35;display:-webkit-box;overflow:hidden}.body-system-count{color:var(--text-muted);font-variant-numeric:tabular-nums;padding-top:.15rem;font-size:.72rem;font-weight:700}.body-rail-empty{color:var(--text-muted);padding:1rem .75rem;font-size:.82rem}.body-viewer-column{flex-direction:column;gap:.5rem;min-width:0;min-height:0;max-height:100%;display:flex;overflow:hidden}.body-svg-wrapper,.body-viewer-shell{border:1px solid var(--border);border-radius:var(--radius-md);background:#0f141c;flex:auto;min-width:0;height:100%;min-height:0;padding:0;overflow:hidden}.body-mesh-chip{color:var(--text-secondary);background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-sm);padding:.4rem .65rem;font-size:.75rem}.body-panel-column{flex-direction:column;min-width:0;min-height:0;max-height:100%;display:flex;overflow:hidden}.body-panel-placeholder{background:var(--bg-card);border:1px dashed var(--border);border-radius:var(--radius-md);text-align:center;height:100%;min-height:0;color:var(--text-muted);flex-direction:column;justify-content:center;align-items:center;gap:.5rem;padding:1.5rem;display:flex;overflow:auto}.body-panel-placeholder h3{color:var(--text-primary);font-size:1rem;font-style:normal;font-weight:600}.body-panel-placeholder p{max-width:28ch;font-size:.84rem;line-height:1.5}.body3d-container{flex-direction:column;height:100%;min-height:0;max-height:100%;display:flex}.body3d-toolbar{color:#c5ced9;background:#161c26;border-bottom:1px solid #ffffff0f;justify-content:space-between;align-items:center;gap:.75rem;padding:.55rem .85rem;font-size:.78rem;display:flex}.body3d-toolbar-title{color:#f0f3f6;font-weight:600}.body3d-toolbar-meta{color:#8a96a5;font-size:.72rem}.body3d-viewer{background:#0b0f14;flex:auto;min-height:0;position:relative;overflow:hidden}.body3d-iframe{border:0;width:100%;height:100%;min-height:0;display:block}.body3d-loader{z-index:3;color:#d7dee7;background:#0b0f14e0;flex-direction:column;justify-content:center;align-items:center;gap:.55rem;font-size:.9rem;display:flex;position:absolute;inset:0}.body3d-loader small{color:#8a96a5;font-size:.75rem}.body3d-error{color:#e8c4c4}.body3d-spinner{border:2px solid #ffffff26;border-top-color:#9eb0c4;border-radius:50%;width:28px;height:28px;animation:.8s linear infinite spin}.body3d-bottom-bar{z-index:2;color:#d7dee7;pointer-events:none;background:linear-gradient(#0000,#000000b8);padding:.55rem .85rem;font-size:.75rem;position:absolute;bottom:0;left:0;right:0}.body3d-clicked-label{z-index:2;color:var(--text-primary);border-radius:var(--radius-sm);max-width:min(70%,320px);box-shadow:var(--shadow-md);background:#fffffff2;align-items:center;gap:.4rem;padding:.35rem .6rem;font-size:.75rem;font-weight:600;display:inline-flex;position:absolute;top:12px;left:12px}.body3d-clicked-dot{background:var(--accent-light);border-radius:50%;flex-shrink:0;width:8px;height:8px}.body3d-attribution{color:#8a96a5;background:#121821;border-top:1px solid #ffffff0d;padding:.4rem .75rem;font-size:.7rem}.body3d-attribution a{color:#b7c6d8}.organ-panel{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);flex-direction:column;height:100%;min-height:0;max-height:100%;display:flex;overflow:hidden}.organ-panel-header{border-bottom:1px solid var(--border);background:var(--bg-input);justify-content:space-between;align-items:flex-start;gap:.5rem;padding:.9rem 1rem;display:flex}.organ-panel-title{align-items:flex-start;gap:.65rem;min-width:0;display:flex}.organ-panel-title h3{color:var(--text-primary);font-size:.95rem;font-style:normal;font-weight:600}.organ-panel-title p{color:var(--text-muted);margin-top:.15rem;font-size:.75rem;line-height:1.4}.organ-panel-mesh{font-family:var(--font-mono);margin-top:.25rem!important;font-size:.7rem!important}.organ-panel-swatch{border-radius:50%;flex-shrink:0;width:10px;height:10px;margin-top:.35rem}.organ-panel-close{cursor:pointer;color:var(--text-muted);border-radius:var(--radius-sm);background:0 0;border:none;padding:.25rem}.organ-panel-close:hover{background:var(--bg-card-hover);color:var(--text-primary)}.organ-panel-count{padding:.55rem 1rem 0}.organ-count-badge{border-radius:999px;align-items:center;padding:.2rem .55rem;font-size:.75rem;font-weight:600;display:inline-flex}.organ-panel-search{border:1px solid var(--border);border-radius:var(--radius-sm);color:var(--text-muted);align-items:center;gap:.4rem;margin:.55rem 1rem 0;padding:.4rem .55rem;display:flex}.organ-panel-search input{width:100%;font-size:.82rem;font-family:var(--font-sans);background:0 0;border:none;outline:none}.organ-panel-body{flex:1;max-height:none;padding:.75rem 1rem 1rem;overflow:auto}.organ-drug-list{flex-direction:column;gap:.5rem;list-style:none;display:flex}.organ-drug-card,.organ-drug-link{border:1px solid var(--border);border-radius:var(--radius-sm);color:inherit;background:var(--bg-card);box-sizing:border-box;min-width:0;padding:.65rem .75rem;text-decoration:none;display:block;overflow:hidden}.organ-drug-card:hover,.organ-drug-link:hover{border-color:var(--accent-light);box-shadow:var(--shadow-sm);text-decoration:none}.odc-header{justify-content:space-between;align-items:flex-start;gap:.5rem;min-width:0;margin-bottom:.25rem;display:flex}.odc-name{color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;flex:1;min-width:0;font-size:.88rem;font-weight:600}.odc-class{color:var(--text-muted);overflow-wrap:anywhere;word-break:break-word;margin-bottom:.25rem;font-size:.72rem}.odc-indication{color:var(--text-secondary);overflow-wrap:anywhere;word-break:break-word;margin-bottom:.4rem;font-size:.76rem;line-height:1.45}.odc-footer{justify-content:space-between;align-items:center;gap:.5rem;min-width:0;display:flex}.odc-id{font-family:var(--font-mono);color:var(--accent-light);overflow-wrap:anywhere;word-break:break-word;min-width:0;font-size:.72rem}.odc-arrow{color:var(--text-muted)}.organ-panel-loading,.organ-panel-error,.organ-panel-empty{text-align:center;color:var(--text-muted);flex-direction:column;justify-content:center;align-items:center;gap:.5rem;padding:2rem 1rem;font-size:.86rem;display:flex}@media (max-width:1100px){.body-explorer-workspace{grid-template-columns:minmax(200px,240px) minmax(0,1fr);height:auto;min-height:0;max-height:none;overflow:visible}.body-panel-column{grid-column:1/-1;max-height:420px}.body-viewer-column,.body-viewer-shell,.body3d-container{height:480px;min-height:420px;max-height:520px}.body-system-rail{max-height:520px}}@media (max-width:760px){.body-explorer-workspace{grid-template-columns:1fr}.body-system-rail{max-height:240px}.body-viewer-column,.body-viewer-shell,.body3d-container{height:400px;max-height:400px}.body-panel-column{max-height:480px}}.odc-id{font-family:var(--font-mono);color:var(--accent-light);font-size:.75rem}.odc-class,.odc-indication{color:var(--text-muted);margin-top:.2rem;font-size:.75rem}.organ-panel-empty,.organ-panel-error,.organ-panel-loading{text-align:center;color:var(--text-muted);padding:1.25rem .5rem;font-size:.88rem}.login-wrap{max-width:400px;margin:3rem auto}.login-wrap h2{margin-bottom:.35rem;font-size:1.35rem;font-weight:600}.login-wrap .subtitle{color:var(--text-secondary);margin-bottom:1.25rem;font-size:.9rem}.login-error{color:#991b1b;border-radius:var(--radius-sm);background:#fee2e2;border:1px solid #fecaca;margin-bottom:.85rem;padding:.65rem .8rem;font-size:.85rem}.animate-in{animation:.28s both fadeIn}@keyframes fadeIn{0%{opacity:0;transform:translateY(4px)}to{opacity:1;transform:none}}@media (prefers-reduced-motion:reduce){.animate-in,*{transition:none!important;animation:none!important}}.spin{animation:.8s linear infinite spin}.filter-tag,.active-filters{flex-wrap:wrap;align-items:center;gap:.35rem;display:flex}.prop-label{color:var(--text-muted);font-size:.72rem}.prop-value{color:var(--text-secondary);font-size:.82rem;font-family:var(--font-mono)}@media (max-width:640px){.page-container{padding:1rem 1rem 2.5rem}.hero{padding:1.35rem 1.15rem}.info-row{grid-template-columns:1fr;gap:.25rem 0;padding:.75rem 0}.info-label{text-transform:uppercase;letter-spacing:.03em;color:var(--text-faint);padding-top:0;font-size:.72rem}.info-row.info-row-table{gap:.45rem}.info-row.info-row-table .info-label{margin-bottom:.15rem}.db-data-table{min-width:0;font-size:.78rem}.db-data-table th,.db-data-table td{white-space:normal;max-width:none;padding:.5rem .55rem}.db-data-table td:first-child{width:30%;min-width:6rem;max-width:none}.db-table-wrap{-webkit-overflow-scrolling:touch;border-radius:var(--radius)}.pdt-toolbar{flex-direction:column;align-items:stretch;gap:.5rem}.pdt-search input{width:100%;min-width:0}.pdt-footer{flex-direction:column;align-items:stretch;gap:.45rem}.pdt-pager{flex-wrap:wrap;justify-content:space-between}.pdt-btn{min-width:40px;min-height:40px}.section-header{padding:.85rem .9rem}.section-body{padding:.25rem .9rem .85rem}.bar-item{grid-template-columns:1fr 40px}.bar-label{grid-column:1/-1}.detail-header{flex-direction:column}.surface-card,.glass-card{padding:1rem 1.1rem}}.pdt{flex-direction:column;gap:.55rem;min-width:0;max-width:100%;display:flex}.pdt-toolbar{color:var(--text-muted);flex-wrap:wrap;justify-content:space-between;align-items:center;gap:.65rem 1.1rem;padding:0 .1rem;font-size:.8rem;display:flex}.pdt-caption{color:var(--text-muted);margin:0;font-size:.78rem;font-weight:600}.pdt-show,.pdt-search{cursor:default;z-index:2;align-items:center;gap:.4rem;display:inline-flex;position:relative}.pdt-show-label{color:var(--text-muted);white-space:nowrap;font-size:.8rem}.pdt-page-size,.pdt-show select,.pdt-search-input,.pdt-search input{font:inherit;border:1px solid var(--border);border-radius:var(--radius-sm);background:var(--bg-card);color:var(--text-primary);cursor:pointer;pointer-events:auto;z-index:3;appearance:auto;-webkit-appearance:menulist;min-height:36px;padding:.35rem .55rem;position:relative}.pdt-search-input,.pdt-search input{cursor:text;min-width:12rem}.pdt-page-size:focus-visible,.pdt-show select:focus-visible,.pdt-search-input:focus-visible,.pdt-search input:focus-visible{outline:2px solid var(--focus);outline-offset:1px;border-color:var(--primary)}.pdt-footer{color:var(--text-muted);flex-wrap:wrap;justify-content:space-between;align-items:center;gap:.5rem 1rem;padding:.15rem .1rem 0;font-size:.78rem;display:flex}.pdt-pager{flex-wrap:wrap;align-items:center;gap:.35rem;display:flex}.pdt-btn{border:1px solid var(--border);background:var(--bg-card);color:var(--text-primary);border-radius:var(--radius-sm);cursor:pointer;min-height:36px;padding:.35rem .65rem;font-size:.8rem}.pdt-btn:hover:not(:disabled){background:var(--bg-hover);border-color:var(--border-hover)}.pdt-btn:disabled{opacity:.45;cursor:not-allowed}.pdt-page-label{font-variant-numeric:tabular-nums;color:var(--text-secondary);padding:0 .25rem;font-weight:600}.pdt-empty{text-align:center;color:var(--text-muted);padding:1rem!important}.pdt-extra{color:var(--text-muted);font-size:.85em}.pdt-cell{white-space:normal;overflow-wrap:break-word;word-break:break-word;max-width:100%;line-height:1.5;display:block}.pdt-cell-extra-link{display:inline}.info-row.info-row-table,.info-row.info-row-full{border-bottom:1px solid #eef1f4;padding:.85rem 0;display:block}.info-row.info-row-table .info-label,.info-row.info-row-full .info-label{color:var(--text-primary);text-transform:none;letter-spacing:0;margin-bottom:.5rem;font-size:.8rem;font-weight:700}.info-row.info-row-table .info-value,.info-row.info-row-full .info-value{max-width:100%}.be2{max-width:1280px;margin:0 auto}.be2-control-band{background:var(--bg-input,#f8fafc);border:1px solid var(--border);border-radius:var(--radius-sm,8px);flex-wrap:wrap;gap:1rem 1.5rem;margin-bottom:1rem;padding:.85rem 1rem;display:flex}.be2-band-label{text-transform:uppercase;letter-spacing:.04em;color:var(--text-muted);margin-bottom:.45rem;font-size:.72rem;font-weight:600}.be2-layers{flex:0 320px}.be2-structures{flex:360px;min-width:220px}.be2-layer-grid{flex-wrap:wrap;gap:.45rem;display:flex}.be2-layer-btn{border:1px solid var(--border);background:var(--bg-card);color:var(--text-secondary);cursor:pointer;font-size:.85rem;font-weight:500;font-family:var(--font-sans);border-radius:10px;align-items:center;gap:.35rem;padding:.5rem .85rem;transition:border-color .15s,background .15s,color .15s;display:inline-flex}.be2-layer-btn:hover{border-color:var(--accent-light,#93c5fd);color:var(--accent,#1d4ed8)}.be2-layer-btn.active{background:var(--accent,#1d4ed8);border-color:var(--accent,#1d4ed8);color:#fff}.be2-structure-list{flex-wrap:wrap;gap:.4rem;display:flex}.be2-structure-btn{border:1px solid var(--border);background:var(--bg-card);cursor:pointer;font-size:.8rem;font-family:var(--font-sans);color:var(--text-secondary);border-radius:999px;padding:.4rem .75rem}.be2-structure-btn:hover{border-color:var(--accent-light,#93c5fd)}.be2-structure-btn.active{color:#fff;background:#0f766e;border-color:#0f766e}.be2-chip{opacity:.85;text-transform:uppercase;margin-left:.3rem;font-size:.65rem}.be2-placeholder{border:1px dashed var(--border);min-height:220px;color:var(--text-secondary);text-align:center;background:#fafaf9;border-radius:12px;justify-content:center;align-items:center;margin-bottom:1rem;padding:1.5rem;display:flex}.be2-stage-shell{grid-template-columns:auto 1fr auto;align-items:stretch;gap:.65rem;margin-bottom:1rem;display:grid}.be2-tools{background:var(--bg-card);border:1px solid var(--border);border-radius:10px;flex-direction:column;gap:.35rem;padding:.4rem;display:flex}.be2-tool-btn{cursor:pointer;min-width:4.4rem;color:var(--text-muted);font-size:.65rem;font-family:var(--font-sans);background:0 0;border:1px solid #0000;border-radius:8px;flex-direction:column;align-items:center;gap:.15rem;padding:.45rem .4rem;display:flex}.be2-tool-btn:hover{background:var(--accent-dim,#eff6ff);color:var(--accent)}.be2-tool-btn.active{background:var(--accent-dim,#eff6ff);border-color:var(--accent-light,#93c5fd);color:var(--accent)}.be2-stage-main{border:1px solid var(--border);background:linear-gradient(#f7f4ef 0%,#ebe6de 100%);border-radius:12px;min-height:420px;position:relative;overflow:hidden}.be2-stage-top{background:#ffffff8c;border-bottom:1px solid #0000000f;justify-content:space-between;align-items:center;padding:.55rem .75rem;display:flex}.be2-stage-title{flex-direction:column;gap:.1rem;margin:0;font-size:1.05rem;font-weight:600;display:flex}.be2-stage-poetic{color:var(--text-muted);font-size:.78rem;font-style:italic;font-weight:400}.be2-info-btn{border:1px solid var(--border);background:var(--bg-card);cursor:pointer;width:36px;height:36px;color:var(--accent,#1d4ed8);border-radius:50%;justify-content:center;align-items:center;display:inline-flex}.be2-info-btn:hover{background:var(--accent-dim,#eff6ff)}.be2-canvas-wrap{height:400px;position:relative}.be2-stage-empty,.be2-stage-error{height:400px;color:var(--text-muted);justify-content:center;align-items:center;font-size:.9rem;display:flex}.be2-stage-hint{color:var(--text-muted);text-align:center;margin:0;padding:.35rem .75rem .55rem;font-size:.72rem}.be2-hotspot-callout{color:#fff;white-space:nowrap;background:#1c1917e0;border-radius:8px;flex-direction:column;gap:.1rem;padding:.35rem .55rem;font-size:.72rem;display:flex;transform:translate(-50%,-120%)}.be2-hotspot-callout strong{font-size:.78rem}.be2-info-panel{background:var(--bg-card);border:1px solid var(--border);border-radius:12px;width:280px;max-height:480px;padding:.85rem 1rem;font-size:.84rem;overflow:auto}.be2-info-head{justify-content:space-between;align-items:flex-start;gap:.5rem;margin-bottom:.5rem;display:flex}.be2-info-head h4{margin:0;font-size:1rem}.be2-sci{color:var(--text-muted);font-size:.85em;font-weight:400}.be2-icon-x{cursor:pointer;color:var(--text-muted);background:0 0;border:none;padding:.15rem}.be2-info-desc{color:var(--text-secondary);margin:0 0 .75rem;line-height:1.45}.be2-info-facts{gap:.4rem;margin:0 0 .75rem;display:grid}.be2-info-facts div{grid-template-columns:5.5rem 1fr;gap:.35rem;display:grid}.be2-info-facts dt{text-transform:uppercase;color:var(--text-muted);margin:0;font-size:.72rem;font-weight:600}.be2-info-facts dd{color:var(--text-primary);margin:0}.be2-info-medical,.be2-info-fun{color:var(--text-secondary);margin:.4rem 0 0;font-size:.8rem;line-height:1.4}.be2-layers-hint{color:var(--text-muted);margin:0;padding:0 .75rem .5rem;font-size:.72rem}.be2-panels{grid-template-columns:repeat(4,minmax(0,1fr));gap:.75rem;margin-bottom:2rem;display:grid}.be2-panels-dim{opacity:.72}.be2-panel{background:var(--bg-card);border:1px solid var(--border);border-radius:12px;min-height:160px;padding:.75rem .85rem}.be2-panel h4{text-transform:uppercase;letter-spacing:.03em;color:var(--text-muted);margin:0 0 .55rem;font-size:.82rem;font-weight:600}.be2-panel-prodrugs{grid-column:span 1;min-width:0}.be2-muted{color:var(--text-muted);margin:.25rem 0;font-size:.82rem}.be2-small{font-size:.75rem}.be2-table-wrap{max-height:220px;margin:0 -.25rem;overflow:auto}.be2-drug-table{border-collapse:collapse;width:100%;font-size:.75rem}.be2-drug-table th,.be2-drug-table td{text-align:left;border-bottom:1px solid var(--border);vertical-align:top;padding:.35rem .4rem}.be2-drug-table th{background:var(--bg-card);text-transform:uppercase;color:var(--text-muted);z-index:1;font-size:.68rem;position:sticky;top:0}.be2-drug-table a{color:var(--accent,#1d4ed8);font-weight:500;text-decoration:none}.be2-drug-table a:hover{text-decoration:underline}.be2-mono{font-family:var(--font-mono,ui-monospace, monospace);font-size:.72rem}.be2-clinical-list{color:var(--text-secondary);margin:0;padding-left:1.1rem;font-size:.82rem;line-height:1.45}.be2-linkish{color:var(--accent,#1d4ed8);cursor:pointer;font-size:.8rem;font-family:var(--font-sans);background:0 0;border:none;padding:0}.be2-btn{border:1px solid var(--accent,#1d4ed8);background:var(--accent,#1d4ed8);color:#fff;cursor:pointer;font-size:.78rem;font-family:var(--font-sans);border-radius:8px;padding:.35rem .7rem}.be2-btn.secondary{background:var(--bg-card);color:var(--text-secondary);border-color:var(--border)}.be2-quiz-q{margin:0 0 .35rem;font-size:.88rem;font-weight:500}.be2-quiz-hint{color:var(--text-muted);margin:0 0 .5rem;font-size:.8rem}.be2-quiz-a{margin:.35rem 0}.be2-quiz-actions{flex-wrap:wrap;gap:.35rem;margin-top:.55rem;display:flex}.be2-notes-list{margin:.4rem 0 0;padding:0;list-style:none}.be2-notes-list li{border-bottom:1px solid var(--border);padding:.35rem 0;position:relative}.be2-note-preview{color:var(--text-muted);margin-top:.15rem;font-size:.75rem}.be2-note-del{float:right;cursor:pointer;color:var(--text-muted);background:0 0;border:none;font-size:1rem;line-height:1}.be2-modal-backdrop{z-index:80;background:#0f172a73;justify-content:center;align-items:center;padding:1rem;display:flex;position:fixed;inset:0}.be2-modal{background:var(--bg-card);border-radius:12px;width:min(420px,100%);padding:1.1rem 1.2rem;box-shadow:0 12px 40px #0000002e}.be2-modal h4{margin:0 0 .65rem}.be2-modal textarea{border:1px solid var(--border);width:100%;font-family:var(--font-sans);resize:vertical;border-radius:8px;padding:.55rem .65rem;font-size:.88rem}.be2-modal-actions{justify-content:flex-end;gap:.5rem;margin-top:.75rem;display:flex}@media (max-width:1100px){.be2-stage-shell{grid-template-columns:auto 1fr}.be2-info-panel{grid-column:1/-1;width:100%;max-height:none}.be2-panels{grid-template-columns:1fr 1fr}}@media (max-width:700px){.be2-tools{flex-flow:wrap}.be2-stage-shell,.be2-panels{grid-template-columns:1fr}.be2-canvas-wrap,.be2-stage-empty{height:320px}}.be2-stage-main{background:linear-gradient(165deg,#f7f1e8 0%,#efe6da 42%,#e7ddd0 100%);box-shadow:inset 0 0 0 1px #ffffff59}.be2-canvas-wrap{height:min(520px,62vh);min-height:380px;position:relative;overflow:hidden}.be2-viewer-glow{pointer-events:none;background:radial-gradient(circle, color-mix(in srgb, var(--be2-accent,#ee7c6a) 28%, transparent), transparent 70%);filter:blur(28px);opacity:.55;z-index:0;border-radius:50%;height:55%;position:absolute;inset:12% 18% auto}.be2-canvas-wrap canvas{z-index:1;touch-action:none;position:relative}.be2-tip-note{z-index:4;-webkit-backdrop-filter:blur(8px);backdrop-filter:blur(8px);pointer-events:none;background:#fffcf7e0;border:1px solid #785a461f;border-radius:14px;width:148px;padding:.65rem .75rem;position:absolute;bottom:2.1rem;left:.75rem;box-shadow:0 8px 24px #281c1414}.be2-tip-note span{letter-spacing:.04em;text-transform:uppercase;color:#a67c6a;margin-bottom:.3rem;font-size:.72rem;font-weight:600;display:block}.be2-tip-note p{color:#4a3f38;margin:0;font-size:.78rem;line-height:1.45}.be2-view-caption{z-index:4;color:#3c30288c;pointer-events:none;font-size:.72rem;position:absolute;bottom:.55rem;right:.85rem}.be2-hotspot-callout{z-index:6;pointer-events:none;position:absolute;transform:translate(-50%,-50%)}.be2-callout-body{pointer-events:auto;color:#fffaf6;border:1px solid color-mix(in srgb, var(--hotspot-color,#ee7c6a) 55%, transparent);background:#201814eb;border-radius:12px;min-width:128px;max-width:200px;padding:.55rem .7rem .55rem .75rem;position:relative;box-shadow:0 10px 28px #140c0847}.be2-callout-body b{margin-bottom:.15rem;font-size:.86rem;font-weight:600;display:block}.be2-callout-body small{color:#fffaf5d1;font-size:.75rem;line-height:1.35;display:block}.be2-callout-close{color:#ffffffb3;cursor:pointer;background:0 0;border:none;padding:.1rem .25rem;font-size:.95rem;line-height:1;position:absolute;top:.2rem;right:.35rem}.be2-hotspot-callout.be2-callout-right .be2-callout-body{transform:translate(18px,-50%)}.be2-hotspot-callout.be2-callout-left .be2-callout-body{transform:translate(calc(-100% - 18px),-50%)}.be2-hotspot-callout.be2-callout-behind .be2-callout-body{opacity:.4}.be2-model-loader{z-index:5;-webkit-backdrop-filter:blur(4px);backdrop-filter:blur(4px);color:#5c4a40;background:#f7f1e88c;flex-direction:column;justify-content:center;align-items:center;gap:.4rem;display:flex;position:absolute;inset:0}.be2-loader-orbit{border:2px solid #ee7c6a40;border-top-color:#ee7c6a;border-radius:50%;width:36px;height:36px;animation:.85s linear infinite be2-spin}@keyframes be2-spin{to{transform:rotate(360deg)}}@media (max-width:700px){.be2-tip-note{display:none}.be2-canvas-wrap{height:360px;min-height:320px}}.be2-model-loader-inline{color:#5c4a40;white-space:nowrap;background:#fffcf7e6;border:1px solid #785a461f;border-radius:14px;flex-direction:column;align-items:center;gap:.35rem;padding:.9rem 1.1rem;font-size:.82rem;display:flex;box-shadow:0 10px 30px #281c141a}.btn-primary{background:var(--bg-header)!important;color:var(--on-primary)!important;box-shadow:none!important;border-color:#0000!important}.btn-primary:hover:not(:disabled){background:var(--bg-header-secondary)!important;color:var(--on-primary)!important}.btn-secondary{color:var(--primary)!important;border-color:var(--border)!important;background:0 0!important}.btn-secondary:hover:not(:disabled){background:var(--primary-soft)!important;border-color:var(--primary)!important;color:var(--primary)!important}.card,.feature-card,.hero{box-shadow:none!important}.drug-page{--drug-rail:11.5rem;--drug-gap:1.25rem;min-width:0;max-width:1200px;margin:0 auto;padding:0 0 4rem}.drug-page-crumb{color:var(--text-muted);flex-wrap:wrap;align-items:center;gap:.4rem;margin:0 0 1.15rem;font-size:.8rem;display:flex}.drug-page-crumb-sep{opacity:.5;flex-shrink:0}.drug-page-crumb-current{color:var(--text-secondary);overflow-wrap:anywhere;min-width:0;font-weight:600}.drug-hero{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg) var(--radius-lg) 0 0;grid-template-columns:minmax(0,1fr) auto;align-items:end;gap:1rem 1.5rem;margin-bottom:0;padding:1.35rem 1.4rem 1.25rem;display:grid}.drug-hero-main{align-items:flex-start;gap:1rem;min-width:0;display:flex}.drug-hero-icon{background:var(--bg-header);width:52px;height:52px;color:var(--text-on-dark);border-radius:10px;flex-shrink:0;justify-content:center;align-items:center;display:flex}.drug-hero-title{letter-spacing:-.025em;color:var(--text-primary);text-wrap:balance;overflow-wrap:anywhere;min-width:0;margin:0 0 .3rem;font-size:clamp(1.35rem,2.4vw,1.85rem);font-style:normal;font-weight:700;line-height:1.15}.drug-hero-ids{color:var(--text-muted);font-size:.8rem;font-family:var(--font-mono);overflow-wrap:anywhere;margin:0 0 .65rem;line-height:1.45}.drug-hero-badges{flex-wrap:wrap;gap:.35rem;display:flex}.drug-hero-actions{flex-wrap:wrap;justify-content:flex-end;gap:.4rem;display:flex}.drug-btn-ghost{border:1px solid var(--border);background:var(--bg);color:var(--text-secondary);border-radius:var(--radius-sm);cursor:pointer;min-height:36px;padding:.4rem .8rem;font-size:.78rem;font-weight:600}.drug-btn-ghost:hover{background:var(--bg-hover);color:var(--text-primary);border-color:var(--border-hover)}.drug-btn-ghost:focus-visible{outline:2px solid var(--focus);outline-offset:2px}.drug-jump{background:var(--bg-card);border:1px solid var(--border);border-radius:0 0 var(--radius-lg) var(--radius-lg);border-top:none;flex-wrap:wrap;gap:.35rem;margin-bottom:1.5rem;padding:.75rem 1.15rem .9rem;display:flex}.drug-jump a{color:var(--text-secondary);background:var(--bg);overflow-wrap:anywhere;white-space:nowrap;border:1px solid #0000;border-radius:999px;align-items:center;max-width:100%;padding:.3rem .7rem;font-size:.76rem;font-weight:600;text-decoration:none;display:inline-flex}.drug-jump a:hover{color:var(--primary);border-color:color-mix(in srgb, var(--primary) 25%, var(--border));background:var(--primary-soft);text-decoration:none}.drug-jump a.is-active{color:var(--primary);border-color:color-mix(in srgb, var(--primary) 35%, var(--border));background:var(--primary-soft)}.drug-identity{grid-template-columns:minmax(0,300px) minmax(0,1fr);align-items:start;gap:1.25rem 1.75rem;margin-bottom:1.75rem;display:grid}.drug-identity-structure{top:calc(var(--nav-height) + .75rem);position:sticky}.drug-structure-frame{background:linear-gradient(180deg, #fafbfc 0%, var(--bg-card) 48%), var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg);min-height:280px;box-shadow:var(--shadow-sm);justify-content:center;align-items:center;padding:1.15rem 1rem 1rem;display:flex}.drug-structure-meta{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);align-items:baseline;gap:.55rem;margin:.65rem 0 0;padding:.55rem .75rem;font-size:.82rem;display:flex}.drug-structure-meta-k{color:var(--text-muted);text-transform:uppercase;letter-spacing:.05em;font-size:.68rem;font-weight:700}.drug-structure-meta-v{font-family:var(--font-mono);color:var(--text-primary);overflow-wrap:anywhere;min-width:0;font-weight:600}.structure-dl{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);margin-top:.75rem;padding:.7rem .75rem .75rem}.structure-dl-compact{background:0 0;border:none;border-radius:0;margin-top:0;padding:0}.structure-dl-head{letter-spacing:.04em;text-transform:uppercase;color:var(--text-muted);align-items:center;gap:.4rem;margin-bottom:.55rem;font-size:.72rem;font-weight:700;display:flex}.structure-dl-actions{flex-wrap:wrap;gap:.35rem;display:flex}.structure-dl-btn{color:var(--primary);background:var(--primary-soft);border:1px solid var(--border);cursor:pointer;border-radius:999px;align-items:center;gap:.28rem;padding:.32rem .55rem;font-family:inherit;font-size:.72rem;font-weight:600;line-height:1.2;text-decoration:none;transition:background .12s,border-color .12s,color .12s;display:inline-flex}.structure-dl-btn:hover:not(:disabled){background:var(--primary);border-color:var(--primary);color:#fff}.structure-dl-btn:disabled{opacity:.55;cursor:wait}.structure-dl-spin{animation:.8s linear infinite structure-dl-spin}@keyframes structure-dl-spin{to{transform:rotate(360deg)}}.structure-dl-note{color:var(--text-faint,#6b7a8d);margin:.55rem 0 0;font-size:.68rem;line-height:1.4}.structure-dl-error{color:#b42318;margin:.45rem 0 0;font-size:.72rem}.structure-dl-empty{color:var(--text-muted);margin:.65rem 0 0;font-size:.78rem}.drug-identity-body{flex-direction:column;gap:1.1rem;min-width:0;display:flex}.drug-facts{background:var(--border);border:1px solid var(--border);border-radius:var(--radius-lg);grid-template-columns:repeat(auto-fill,minmax(min(100%,132px),1fr));gap:1px;margin:0;padding:0;display:grid;overflow:hidden}.drug-fact{background:var(--bg-card);min-width:0;margin:0;padding:.75rem .85rem}.drug-fact dt{text-transform:uppercase;letter-spacing:.05em;color:var(--text-muted);margin:0 0 .25rem;font-size:.66rem;font-weight:700}.drug-fact dd{color:var(--text-primary);overflow-wrap:anywhere;word-break:break-word;margin:0;font-size:.86rem;font-weight:600;line-height:1.35}.drug-fact dd.mono{font-family:var(--font-mono);font-size:.8rem;font-weight:500}.drug-prose-stack{flex-direction:column;gap:.65rem;display:flex}.drug-prose-block{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg);margin:0;padding:1.05rem 1.2rem 1.15rem}.drug-prose-h{color:var(--primary);letter-spacing:.04em;text-transform:uppercase;margin:0 0 .45rem;font-size:.72rem;font-style:normal;font-weight:700}.drug-prose{color:var(--text-secondary);overflow-wrap:anywhere;text-wrap:pretty;max-width:68ch;margin:0;font-size:.92rem;line-height:1.68}.drug-pathway-feature{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg);scroll-margin-top:calc(var(--nav-height) + .85rem);box-shadow:var(--shadow-sm);margin-bottom:1.85rem;padding:0;overflow:hidden}.drug-pathway-feature-head{background:color-mix(in srgb, var(--bg-header) 4%, var(--bg-card));border-bottom:1px solid var(--border);color:var(--primary);align-items:center;gap:.55rem;padding:.85rem 1.15rem;display:flex}.drug-pathway-feature-head h2{color:var(--text-primary);letter-spacing:-.01em;margin:0;font-size:.95rem;font-style:normal;font-weight:700}.drug-pathway-feature .pathway-panel{box-shadow:none!important;background:0 0!important;border:none!important;margin:0!important;padding:.85rem 1rem 1rem!important}.drug-pathway-feature .pathway-panel-header h3{clip:rect(0, 0, 0, 0);white-space:nowrap;border:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}.drug-layout{grid-template-columns:var(--drug-rail) minmax(0, 1fr);align-items:start;gap:1.5rem 1.75rem;display:grid}.drug-toc{top:calc(var(--nav-height) + .85rem);max-height:calc(100vh - var(--nav-height) - 1.5rem);padding:0;position:sticky;overflow-y:auto}.drug-toc-title{text-transform:uppercase;letter-spacing:.07em;color:var(--text-faint);margin:0 0 .65rem;font-size:.68rem;font-weight:700}.drug-toc-nav{flex-direction:column;gap:.05rem;display:flex}.drug-toc-link{color:var(--text-muted);border-radius:var(--radius-sm);overflow-wrap:anywhere;min-width:0;padding:.4rem .55rem;font-size:.78rem;line-height:1.35;text-decoration:none;display:block}.drug-toc-link:hover{color:var(--primary);background:var(--bg-hover);text-decoration:none}.drug-toc-link.is-active{color:var(--primary);background:var(--primary-soft);font-weight:700}.drug-sections{flex-direction:column;gap:.85rem;min-width:0;display:flex}.drug-section{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg);scroll-margin-top:calc(var(--nav-height) + .85rem);box-shadow:var(--shadow-sm);overflow:visible}.drug-section-toggle{cursor:pointer;text-align:left;width:100%;min-height:54px;font:inherit;color:inherit;border-radius:var(--radius-lg);background:0 0;border:none;align-items:center;gap:.7rem;margin:0;padding:1rem 1.2rem;display:flex}.drug-section-toggle:hover{background:color-mix(in srgb, var(--bg-hover) 80%, transparent)}.drug-section-toggle:focus-visible{outline:2px solid var(--focus);outline-offset:-2px}.drug-section-icon{background:var(--primary-soft);width:34px;height:34px;color:var(--primary);border-radius:8px;flex-shrink:0;justify-content:center;align-items:center;display:flex}.drug-section-title{min-width:0;color:var(--text-primary);letter-spacing:-.015em;overflow-wrap:anywhere;flex:1;font-size:1.02rem;font-style:normal;font-weight:700}.drug-section-count{font-variant-numeric:tabular-nums;color:var(--text-muted);background:var(--bg);border:1px solid var(--border);border-radius:999px;flex-shrink:0;padding:.18rem .55rem;font-size:.7rem;font-weight:700}.drug-section-chevron{color:var(--text-muted);transition:transform var(--dur-fast) var(--ease-out);flex-shrink:0;font-size:.85rem}.drug-section-chevron.open{transform:rotate(180deg)}.drug-section-body{border-top:1px solid var(--border);background:color-mix(in srgb, var(--bg) 55%, var(--bg-card));padding:.15rem 1.2rem 1.25rem}.drug-section-body[hidden]{display:none}.drug-fields{flex-direction:column;gap:0;display:flex}.drug-field{border-bottom:1px solid color-mix(in srgb, var(--border) 80%, transparent);min-width:0;padding:.95rem 0}.drug-field:last-child{border-bottom:none;padding-bottom:.2rem}.drug-field-label{color:var(--text-muted);letter-spacing:.01em;margin-bottom:.4rem;font-size:.76rem;font-weight:700}.drug-field-value{min-width:0;max-width:100%;color:var(--text-secondary);overflow-wrap:anywhere;font-size:.9rem;line-height:1.55}.drug-field-kv{grid-template-columns:minmax(7.5rem,11.5rem) minmax(0,1fr);align-items:start;gap:.5rem 1.35rem;display:grid}.drug-field-kv .drug-field-label{margin-bottom:0;padding-top:.12rem}.drug-field-prose .drug-field-value{max-width:68ch;color:var(--text-secondary);line-height:1.65}.drug-field-table{padding:1.05rem 0}.drug-field-table .drug-field-label{color:var(--text-primary);margin-bottom:.6rem;font-size:.86rem}.drug-field-table .drug-field-value{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-md);width:100%;padding:.15rem;overflow:hidden}.drug-field-table .pdt{padding:.65rem .7rem .75rem}.drug-field-table .db-table-wrap{box-shadow:none;border:none;border-top:1px solid var(--border);border-radius:0;margin-top:.45rem}.drug-ext-grid{grid-template-columns:repeat(auto-fill,minmax(min(100%,190px),1fr));gap:.5rem;padding-top:.55rem;display:grid}.drug-ext-card{border:1px solid var(--border);border-radius:var(--radius-md);background:var(--bg-card);min-width:0;transition:border-color var(--dur-fast) var(--ease-out), background var(--dur-fast) var(--ease-out);flex-direction:column;gap:.3rem;padding:.75rem .85rem;text-decoration:none;display:flex}.drug-ext-card:hover{border-color:color-mix(in srgb, var(--primary) 40%, var(--border));background:var(--primary-soft);text-decoration:none}.drug-ext-card:focus-visible{outline:2px solid var(--focus);outline-offset:2px}.drug-ext-db{color:var(--text-muted);text-transform:uppercase;letter-spacing:.04em;font-size:.68rem;font-weight:700}.drug-ext-id{font-size:.84rem;font-weight:600;font-family:var(--font-mono);color:var(--primary);overflow-wrap:anywhere;word-break:break-word}@media (max-width:980px){.drug-layout{grid-template-columns:1fr}.drug-toc{max-height:none;position:relative;top:0;overflow:visible}.drug-toc-nav,.drug-toc-title{display:none}.drug-identity-structure{position:static}}@media (max-width:720px){.drug-identity{grid-template-columns:1fr}.drug-hero{border-radius:var(--radius-lg) var(--radius-lg) 0 0;grid-template-columns:1fr;padding:1.05rem 1rem}.drug-jump{margin-bottom:1.15rem}.drug-jump a{white-space:normal}.drug-hero-title{font-size:1.35rem}.drug-hero-actions{justify-content:flex-start}.drug-field-kv{grid-template-columns:1fr;gap:.25rem}.drug-section-toggle{padding:.9rem 1rem}.drug-section-body{padding:.1rem 1rem 1rem}.drug-field-table .pdt{padding:.5rem}}@media (prefers-reduced-motion:reduce){.drug-section-chevron,.drug-toc-link,.drug-ext-card,.drug-btn-ghost,.drug-jump a{transition:none}}.hover\:bg-\[var\(--bg-hover\)\]:hover{background-color:var(--bg-hover)}.hover\:bg-\[var\(--error-soft\)\]:hover{background-color:var(--error-soft)}.hover\:bg-white\/15:hover{background-color:#ffffff26}.hover\:text-\[var\(--error\)\]:hover{color:var(--error)}.hover\:text-\[var\(--text\)\]:hover{color:var(--text)}.hover\:underline:hover{text-decoration-line:underline}.disabled\:opacity-40:disabled{opacity:.4}@media (min-width:640px){.sm\:col-span-2{grid-column:span 2/span 2}.sm\:block{display:block}.sm\:grid-cols-2{grid-template-columns:repeat(2,minmax(0,1fr))}.sm\:grid-cols-6{grid-template-columns:repeat(6,minmax(0,1fr))}.sm\:gap-3{gap:.75rem}.sm\:px-3{padding-left:.75rem;padding-right:.75rem}.sm\:px-5{padding-left:1.25rem;padding-right:1.25rem}.sm\:px-6{padding-left:1.5rem;padding-right:1.5rem}.sm\:py-3{padding-top:.75rem;padding-bottom:.75rem}.sm\:text-3xl{font-size:1.875rem;line-height:2.25rem}.sm\:text-\[15px\]{font-size:15px}}@media (min-width:768px){.md\:flex{display:flex}.md\:inline-flex{display:inline-flex}.md\:hidden{display:none}.md\:flex-col{flex-direction:column}}@media (min-width:1024px){.lg\:col-span-5{grid-column:span 5/span 5}.lg\:col-span-7{grid-column:span 7/span 7}.lg\:block{display:block}.lg\:grid-cols-12{grid-template-columns:repeat(12,minmax(0,1fr))}.lg\:grid-cols-2{grid-template-columns:repeat(2,minmax(0,1fr))}.lg\:px-8{padding-left:2rem;padding-right:2rem}}@media (min-width:1280px){.xl\:grid-cols-3{grid-template-columns:repeat(3,minmax(0,1fr))}}